The renoprotective potential of endothelin receptor antagonists

The endothelin system has been identified as having a substantial role in renal failure, both acute and chronic. Beside its well characterised haemodynamic effects, its mitogenic and pro-fibrotic properties have gained increased interest in the pathophysiology of chronic renal failure. This review o...

Full description

Saved in:
Bibliographic Details
Published inExpert opinion on investigational drugs Vol. 9; no. 5; p. 1041
Main Authors Knoll, T, Schaub, M, Birck, R, Braun, C, Juenemann, K P, Rohmeiss, P
Format Journal Article
LanguageEnglish
Published England 01.05.2000
Subjects
Animals
Endothelin Receptor Antagonists
Endothelins - physiology
Humans
Kidney Diseases - prevention & control
Renal Insufficiency - drug therapy
Renal Insufficiency - physiopathology
Online AccessGet more information

Cover

More Information
Summary:The endothelin system has been identified as having a substantial role in renal failure, both acute and chronic. Beside its well characterised haemodynamic effects, its mitogenic and pro-fibrotic properties have gained increased interest in the pathophysiology of chronic renal failure. This review outlines the role of endothelin in the pathogenesis of various renal diseases with a special focus on the potential of blocking this system with endothelin receptor antagonists. So far, most data were derived from animal models, but they provide strong evidence that endothelin receptor antagonists may represent a powerful therapeutic strategy in ameliorating the course of acute and chronic renal failure.
ISSN:1354-3784
DOI:10.1517/13543784.9.5.1041