Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: Antioxidant-prooxidant balance

The effects of ozone treatment on the injury associated to hepatic ischemia-reperfusion (I/R) was evaluated. Ozone treatment (1 mg/kg daily during 10 days by rectal insufflation) is shown to be protective as it attenuated the increases in transaminases (AST, ALT) and lactate levels observed after I/...

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Published inFree radical research Vol. 31; no. 3; pp. 191 - 196
Main Authors Peralta, C., León, O.S., Xaus, C., Prats, N., Jalil, E.C., Planell, E. Sala, Puig-Parellada, P., Gelpí, E., Roselló-Catafau, J.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.1999
Taylor & Francis
Subjects
Animals
Antioxidants - metabolism
glutathione
Glutathione - metabolism
ischemia-reperfusion
Lactates - metabolism
Liver - blood supply
Liver - drug effects
Liver - pathology
Male
Necrosis
Oxidants - metabolism
Oxidative Stress - drug effects
Ozone
Ozone - pharmacology
Ozone - therapeutic use
Rats
Rats, Wistar
reactive oxygen species
Reactive Oxygen Species - metabolism
Reperfusion
Reperfusion Injury - metabolism
Reperfusion Injury - prevention & control
superoxide dismutase
Superoxide Dismutase - drug effects
Superoxide Dismutase - metabolism
Transaminases - drug effects
Transaminases - metabolism
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Summary:The effects of ozone treatment on the injury associated to hepatic ischemia-reperfusion (I/R) was evaluated. Ozone treatment (1 mg/kg daily during 10 days by rectal insufflation) is shown to be protective as it attenuated the increases in transaminases (AST, ALT) and lactate levels observed after I/R. I/R leads to a decrease in endogenous antioxidant (SOD and glutathione) and an increase in reactive oxygen species (H2O2) with respect to the control group. However, ozone treatment results in a preservation (glutathione) or increase (SOD) in antioxidant defense and maintains H2O2 at levels comparable to those in the control group. The present study reports a protective effect of ozone treatment on the injury associated to hepatic I/R. The effectiveness of ozone could be related to its action on endogenous antioxidants and prooxidants balance in favour of antioxidants, thus attenuating oxidative stress.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715769900300741