An in vitro study of boronated porphyrins for potential use in boron neutron capture therapy

A series of boronated hematoporphyrin analogs differing in lipophilicity and in the length of the di-ether side chains, and their zinc derivatives were evaluated for use in boron neutron capture therapy. The porphyrins displayed no inherent cytotoxicity towards V79 cells at a concentration of 300 μM...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 3; no. 10; pp. 2017 - 2022
Main Authors Woodburn, Kathryn, Phadke, Avinash S., Morgan, Alan R.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.1993
Elsevier
Subjects
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
Antineoplastic agent
Cell culture
Neutron capture
Cytotoxicity
Lipophily
Neutron therapy
Radiotherapy
In vitro
Uptake
Cell line
Treatment
Porphyrin
Tumor cell
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Summary:A series of boronated hematoporphyrin analogs differing in lipophilicity and in the length of the di-ether side chains, and their zinc derivatives were evaluated for use in boron neutron capture therapy. The porphyrins displayed no inherent cytotoxicity towards V79 cells at a concentration of 300 μM. Cellular uptake varied as a function of lipophilicity and metallation. Amphiphilic carboranyl porphyrins were tested for uptake into V79 cells. Uptake correlated with the lipophilciity of the porphyrin used, for the metal-free series.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)81006-4