Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy

Although a great deal of emphasis has been placed on the vasculopathy that is associated with oxygen-induced retinopathy (OIR), our studies also revealed significant and irreversible structural (retinal histology) and functional (scotopic and photopic electroretinograms) impairments that were signif...

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Bibliographic Details
Published inDocumenta ophthalmologica Vol. 120; no. 1; pp. 61 - 66
Main Authors Dorfman, A. L., Chemtob, S., Lachapelle, P.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.02.2010
Springer Nature B.V
Subjects
Animals
Animals, Newborn
Disease Models, Animal
Electroretinography
Humans
Hyperoxia - physiopathology
Infant, Newborn
Medicine
Medicine & Public Health
Ophthalmology
Oxygen - toxicity
Rats
Retina - physiopathology
Retinal Neovascularization - physiopathology
Retinal Vessels - drug effects
Retinopathy of Prematurity - physiopathology
Review Article
Oxygen
Histology
Retinopathy
Electroretinogram
Neonatal rat
Vasculature
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Summary:Although a great deal of emphasis has been placed on the vasculopathy that is associated with oxygen-induced retinopathy (OIR), our studies also revealed significant and irreversible structural (retinal histology) and functional (scotopic and photopic electroretinograms) impairments that were significantly more severe in pigmented Long–Evans rats compared to the more commonly used albino Sprague Dawley rats. In the following pages, we will highlight what we have learned about the retinal pathophysiological processes of OIR taking place in strains of both rats with the hope that this will trigger investigations into new therapeutic strategies to complement those geared at preventing the vasculopathy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-009-9208-3