Ubiquitin-mediated proteolysis: biological regulation via destruction
The ubiquitin proteolytic system plays an important role in a broad array of basic cellular processes. Among these are regulation of cell cycle, modulation of the immune and inflammatory responses, control of signal transduction pathways, development and differentiation. These complex processes are...
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Published in | BioEssays Vol. 22; no. 5; pp. 442 - 451 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.05.2000
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Subjects | |
Online Access | Get full text |
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Summary: | The ubiquitin proteolytic system plays an important role in a broad array of basic cellular processes. Among these are regulation of cell cycle, modulation of the immune and inflammatory responses, control of signal transduction pathways, development and differentiation. These complex processes are controlled via specific degradation of a single or a subset of proteins. Degradation of a protein by the ubiquitin system involves two successive steps, conjugation of multiple moieties of ubiquitin and degradation of the tagged protein by the 26S proteasome. An important question concerns the identity of the mechanisms that underlie the high degree of specificity of the system. Substrate recognition is governed by a large family ubiquitin ligases that recognize the substrates, bind them and catalyze/facilitate their interaction with ubiquitin. BioEssays 22:442—451, 2000. © 2000 John Wiley & Sons, Inc. |
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Bibliography: | a TMR grant from the European Community the Foundation for Promotion of Research at the Technion research grant administered by the Vice President of the Technion for (to A.C.) ark:/67375/WNG-DM9W60M3-8 istex:C1B85882B4582491A077ED80432E12E5120A52AD the Israel Science Foundation founded by the Israeli Academy of Sciences and Humanities-Centers of Excellence Program the German-Israeli Project Cooperation (DIP) ArticleID:BIES6 the German-Israeli Foundation for Scientific Research and Development (GIF) the National Institutes of Health (NIH; to A.L.S.) the Israel Cancer Society the US-Israel Binational Science Foundation (to A.C. and A.L.S.) ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0265-9247 1521-1878 |
DOI: | 10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q |