Minichromosome maintenance 2 expression is correlated with mode of invasion and prognosis in oral squamous cell carcinomas

• Published in: Journal of oral pathology & medicine Vol. 32; no. 8; pp. 468 - 474
• Main Authors: Kodani, Isamu, Osaki, Mitsuhiko, Shomori, Kohei, Araki, Kunio, Goto, Eizo, Ryoke, Kazuo, Ito, Hisao
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.09.2003
• Subjects: apoptosis; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - secondary; Cell Cycle Proteins - analysis; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases - antagonists & inhibitors; Cyclins - analysis; Dentistry; differentiation; DNA Replication; DNA, Neoplasm - analysis; Enzyme Inhibitors - analysis; Follow-Up Studies; Humans; In Situ Nick-End Labeling; Ki-67 Antigen - analysis; Middle Aged; minichromosome maintenance 2 (MCM2); Minichromosome Maintenance Complex Component 2; mode of carcinoma invasion; Mouth Neoplasms - pathology; Neoplasm Invasiveness; Nuclear Proteins - analysis; Prognosis; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Proteins - analysis
• ISSN: 0904-2512; 1600-0714
• DOI: 10.1034/j.1600-0714.2003.00116.x

Background:  This study examined the immunohistochemical expression of cell‐cycle related molecules as well as cell proliferation and pathologic findings in oral squamous cell carcinoma (SCC) in order to clarify their pathobiologic and prognostic significance. Methods:  A total of 46 oral SCC specimens were analyzed using Ki‐67, minichromosome maintenance 2 (MCM2), p53, p27, p21, and TUNEL. Aspects including tumor differentiation, mode of carcinoma invasion, tumor metastasis, and patient prognosis were compared among the specimens. Results:  A significantly higher MCM2 labeling index (LI) was observed in the moderately differentiated SCCs when compared to the well‐differentiated SCCs (P < 0.05). The higher MCM2 LI was correlated with mode of invasion Grade 4 (infiltrative growth) and patient prognosis. In contrast, the LIs of Ki‐67, TUNEL‐signal, p53, p27, and p21 were not correlated with patient prognosis. Conclusion:  Higher MCM2 LI provides useful information for patient prognosis in oral SCCs.