Serum P-selectin Level During Controlled Ovarian Hyperstimulation - a Preliminary Report

• Published in: American journal of reproductive immunology (1989) Vol. 52; no. 2; pp. 139 - 142
• Main Authors: Orvieto, Raoul, Badir, Walid, Bar, Jacob, La Marca, Antonio, Ashkenazi, Jacob, Avrech, Ori M., Fisch, Benjamin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing 01.08.2004
• Subjects: Adult; Dinoprostone - blood; Female; Gonadotropins - pharmacology; Humans; Inflammation; OHSS; Ovarian Hyperstimulation Syndrome - chemically induced; Ovarian Hyperstimulation Syndrome - metabolism; Ovary - drug effects; Ovary - metabolism; ovulation induction; P-selectin; P-Selectin - blood; Progesterone - blood; thrombosis
• ISSN: 1046-7408; 1600-0897
• DOI: 10.1111/j.1600-0897.2004.00194.x

Objective:  To measure levels of serum P‐selectin in patients undergoing controlled ovarian hyperstimulation (COH) cycles and to determine their possible correlation to COH variables. Setting:  Large university‐based infertility and in vitro fertilization unit. Patients:  Fourteen consecutive patients undergoing our routine COH protocol for unexplained infertility. Interventions and Main Outcome Measures:  Blood was drawn three times during the COH cycle: (1) day 2 or 3 of the menstrual cycle, before gonadotropin treatment (Day‐0); (2) day of or prior to human chorionic gonadotropin (hCG) administration (Day‐hCG); and (3) day of ovulation (Day‐OVU). Serum levels of sex steroids and P‐selectin were compared among the three time points. P‐selectin was measured with a commercial quantitative sandwich immunoassay technique. To reduce interpatient variability, the percent difference between the Day‐0 (non‐stimulated, basal) level and the Day‐hCG and Day‐OVU levels was calculated. Results:  P‐selectin level on Day‐hCG was significantly higher than on Day‐0 (P < 0.05) and non‐significantly higher than on Day‐OVU (P < 0.12). No significant correlations were observed between serum P‐selectin and patient age, amount of gonadotropins used, or estradiol or progesterone level. Conclusion:  The increase in serum P‐selectin level during COH until peak estradiol suggests that COH may potentiate a state of platelet activation which is substantially attenuated after hCG administration.