Reactivity of Routine HIV Antibody Tests in Children With Perinatally Acquired HIV-1 in England: Cross-sectional Analysis

We assessed HIV antibody prevalence in children with perinatally acquired HIV in England. Eighteen percent (10/55) of those starting combination antiretroviral therapy <6 months of age were seronegative at median age 9.1 years and had lower viral load at diagnosis and combination antiretroviral t...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 38; no. 2; p. 146
Main Authors Fidler, Katy J, Foster, Caroline, Lim, Emma J, Patel, Amie, Welch, Steven, Menson, Esse, Klein, Nigel, Judd, Ali
Format Journal Article
LanguageEnglish
Published United States 01.02.2019
Subjects
Adolescent
Anti-Retroviral Agents - therapeutic use
Child
Child, Preschool
Cross-Sectional Studies
England
Female
HIV Antibodies - blood
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1 - immunology
HIV-1 - isolation & purification
Humans
Infant
Infant, Newborn
Male
Viral Load
England
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Summary:We assessed HIV antibody prevalence in children with perinatally acquired HIV in England. Eighteen percent (10/55) of those starting combination antiretroviral therapy <6 months of age were seronegative at median age 9.1 years and had lower viral load at diagnosis and combination antiretroviral therapy start and fewer viral rebounds, than 45 of 55 seropositives. Implications for patient selection for HIV cure research, and interpretation of routine antibody testing, are discussed.
ISSN:1532-0987
DOI:10.1097/INF.0000000000002143