Hypersensitivity to pancreatic extracts in parents of patients with cystic fibrosis

Because immediate hypersensitivity reactions can occur in individuals exposed to powdered pancreatic extracts, 36 patients with cystic fibrosis and 51 parents of such patients were studied for evidence of sensitization. Sensitivity to the extracts as evidenced by history and skin testing was infrequ...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 59; no. 1; pp. 35 - 40
Main Authors Twarog, Frank J., Weinstein, Steven F., Khaw, Kon Taik, Strieder, Denise J., Colten, Harvey R.
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 1977
Subjects
Adult
Child
Child, Preschool
Cystic Fibrosis - immunology
Histamine Release
Humans
Hypersensitivity, Immediate - chemically induced
Immunization, Passive
Pancreatic Extracts - pharmacology
Respiratory Function Tests
Skin Tests
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Summary:Because immediate hypersensitivity reactions can occur in individuals exposed to powdered pancreatic extracts, 36 patients with cystic fibrosis and 51 parents of such patients were studied for evidence of sensitization. Sensitivity to the extracts as evidenced by history and skin testing was infrequent in the children with cystic fibrosis. However, skin testing for immediate hypersensitivity with either crude pancreatic extracts or inactivated trypsin correlated well in their parents with a history of clinical symptoms. IgE mediation of these reactions in sensitized individuals was demonstrated by antigen-induced histamine release from leukocytes, passive transfer studies, and immediate response to inhalation challenge.
ISSN:0091-6749
1097-6825
DOI:10.1016/0091-6749(77)90174-9