Facile synthesis of Zn-based metal-organic framework in the presence of carboxymethyl cellulose: A safe carrier for ibuprofen

• Published in: International journal of biological macromolecules Vol. 191; pp. 531 - 539
• Main Authors: Javanbakht, Siamak, Pooresmaeil, Malihe, Namazi, Hassan, Heydari, Abolfazl
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.11.2021
• Subjects: adsorption; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; biopolymers; Carboxymethyl cellulose; carboxymethylcellulose; Carboxymethylcellulose Sodium - chemistry; Cell Survival - drug effects; cell viability; coordination polymers; desorption; dicarboxylic acids; Drug Carriers - chemical synthesis; Drug Carriers - toxicity; Drug delivery; HEK293 Cells; Humans; Ibuprofen; Ibuprofen - administration & dosage; Metal-organic framework; Metal-Organic Frameworks - chemical synthesis; Metal-Organic Frameworks - toxicity; porosity; sorption isotherms; surface area; synthesis; zinc; Zinc - chemistry; Carboxymethyl cellulose; Metal-organic framework; Drug delivery; Ibuprofen
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2021.09.033

Fabrication of porous materials with a high surface area affords a great interest to achieve a system with a prolonged drug release manner. In this context, the subject of this work is to describe a novel green one-pot synthesis route for the growth of metal-organic framework (MOF) from zinc metal (Zn) and 1, 4-benzene dicarboxylic acid (BDC) in the vicinity of the carboxymethyl cellulose (CMC), which homogeneously confined in the biopolymeric chains. The synthesized Zn (BDC)@CMC was characterized and confirmed using different analyses. N2 adsorption/desorption isotherms determined the mean diameter of pore size of about 2.3993 nm. Ibuprofen (IBU) as a model drug was highly loaded to the Zn(BDC)@CMC by immersing in the drug solution; 50.95%. The in vitro IBU release study indicated that the Zn(BDC)@CMC has more attractive performances than pristine Zn(BDC). The IBU release occurred via the Fickian mechanism. Isotherm studies showed that the IBU adsorption on obeys from Langmuir isotherm; R2 0.9623. The MTT results revealed the HEK 293A cell viability of higher than 90% for Zn(BDC)@CMC that confirms its cytocompatibility. Overall, obtained results confirm the functionality of CMC biopolymer for in situ growth of MOF in the presence of it due to having the reactive nature. •CMC was selected for the growth of Zn(BDC) in the presence of it because of its high functionally.•The microporous biopolymeric structure was successfully prepared via the growth of the Zn-based MOF.•IBU as a model drug was successfully encapsulated in the Zn(BDC)@CMC and Zn(BDC).•IBU@Zn(BDC)@CMC showed sustained, prolonged, and controlled-release performances.•Zn(BDC)@CMC exhibited a cytocompatibility nature toward HEK 293A cells.