Anticancer nano-delivery systems based on bovine serum albumin nanoparticles: A critical review

Among the health-promotional protein-based vehicles, bovine serum albumin nanoparticles (BSA NPs) are particularly interesting. Meeting requirements e. g., non-toxicity, non-immunogenicity, biodegradability, biocompatibility, and high drug-binding capacity, has introduced BSA NPs as a promising cand...

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Bibliographic Details
Published inInternational journal of biological macromolecules Vol. 193; no. Pt A; pp. 528 - 540
Main Authors Solanki, Raghu, Rostamabadi, Hadis, Patel, Sunita, Jafari, Seid Mahdi
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.12.2021
Subjects
Animals
Anti-cancer drugs
antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
biocompatibility
biodegradability
bovine serum albumin
Bovine serum albumin (BSA)
Cancer therapy
Cell Line, Tumor
Delivery systems
Drug Carriers - chemistry
Drug Delivery Systems
Humans
nanocapsules
Nanoparticle Drug Delivery System - chemistry
Nanoparticle Drug Delivery System - pharmacology
Nanoparticles
Nanoparticles - chemistry
Particle Size
Serum Albumin, Bovine - chemistry
Serum Albumin, Bovine - pharmacology
Nanoparticles
Bovine serum albumin (BSA)
Cancer therapy
Delivery systems
Anti-cancer drugs
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Summary:Among the health-promotional protein-based vehicles, bovine serum albumin nanoparticles (BSA NPs) are particularly interesting. Meeting requirements e. g., non-toxicity, non-immunogenicity, biodegradability, biocompatibility, and high drug-binding capacity, has introduced BSA NPs as a promising candidate for efficient anti-cancer drug delivery and its application is now a rapidly-growing strategy to promote cancer therapy. Nevertheless, the leverage of such carriers requires an in-depth understanding of structural/physicochemical features of the BSA molecule and its derived nanovehicles, together with the utilized nano-formulation approaches, effective variables in delivery mechanism, specific shortfalls, and recent nanoencapsulation progresses. The current review highlights the novel advances in the application of BSA NPs to engineer drug vehicles for delivering anti-cancer agents. The factors influencing the efficiency of the therapeutics in such nano-delivery systems, alongside their advantaged and limitations are also discussed. Biomedical applications of BSA NPs. [Display omitted]
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ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2021.10.040