Surveillance in patients with stage I testicular nonseminomatous germ cell tumors

• Published in: Cancer investigation Vol. 11; no. 1; p. 10
• Main Authors: Gez, E, Wygoda, M, Nussbaum, N, Figer, A, Gil, R I, Inbal, M
• Format: Journal Article
• Language: English
• Published: England 1993
• Subjects: Adolescent; Adult; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local - diagnosis; Neoplasm Staging; Neoplasms, Germ Cell and Embryonal - pathology; Neoplasms, Germ Cell and Embryonal - surgery; Neoplasms, Germ Cell and Embryonal - therapy; Orchiectomy; Prospective Studies; Testicular Neoplasms - pathology; Testicular Neoplasms - surgery; Testicular Neoplasms - therapy
• DOI: 10.3109/07357909309020255
• ISSN: 0735-7907

Fourteen patients with testicular nonseminomatous germ cell tumor, clinical stage I were entered into a surveillance study. Median age was 31 (range 18-58). Three patients had pure tumor, and 11, mixed tumor. In 2 patients, vascular invasion was noted, and in 1, involvement of the spermatic cord. Serum alpha fetoprotein and beta subunit choriogonadotropin were high in 9 and in 3 patients, respectively. In median follow-up of 21 months (range 2-63), 3 patients relapsed: 1 had inguinal lymphadenopathy and 2 had lung metastases at 12, 4, and 16 months, respectively. Salvage chemotherapy PEB and PVB achieved complete response in the latter 2 patients for 6 and 49 months. Except for 1 patient lost to follow-up, all are alive.