Microfluidic neural probes: in vivo tools for advancing neuroscience
Microfluidic neural probes hold immense potential as in vivo tools for dissecting neural circuit function in complex nervous systems. Miniaturization, integration, and automation of drug delivery tools open up new opportunities for minimally invasive implants. These developments provide unprecedente...
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| Published in | Lab on a chip Vol. 17; no. 8; pp. 146 - 1435 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
11.04.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Microfluidic neural probes hold immense potential as
in vivo
tools for dissecting neural circuit function in complex nervous systems. Miniaturization, integration, and automation of drug delivery tools open up new opportunities for minimally invasive implants. These developments provide unprecedented spatiotemporal resolution in fluid delivery as well as multifunctional interrogation of neural activity using combined electrical and optical modalities. Capitalizing on these unique features, microfluidic technology will greatly advance
in vivo
pharmacology, electrophysiology, optogenetics, and optopharmacology. In this review, we discuss recent advances in microfluidic neural probe systems. In particular, we will highlight the materials and manufacturing processes of microfluidic probes, device configurations, peripheral devices for fluid handling and packaging, and wireless technologies that can be integrated for the control of these microfluidic probe systems. This article summarizes various microfluidic implants and discusses grand challenges and future directions for further developments.
This review discusses recent advances in microfluidic neural probe systems, which hold immense potential as
in vivo
tools for manipulating neural circuits in complex nervous systems. |
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| Bibliography: | Dr. Joo Yong Sim received his BS degree in mechanical and aerospace engineering from Seoul National University and his MS and PhD degrees in mechanical engineering from Stanford University. Since then, he has been working as a researcher in the Electronics and Telecommunications Research Institute. His research is primarily in the area of biomedical engineering and biophysics focusing on the development of biomedical sensors and actuators using microelectromechanical systems, microfabricated devices, biophotonics and advanced microscopy technologies. Dr. Jordan G. McCall is an Assistant Professor at the Center for Clinical Pharmacology in the Department of Anesthesiology at Washington University in St. Louis School of Medicine and Department of Pharmaceutical and Administrative Sciences at St. Louis College of Pharmacy. He received his BA, BS, and MPH degrees from the University of Missouri-Columbia and his PhD degree in neurosciences from Washington University in St. Louis. Dr. McCall's laboratory studies the neural mechanisms of stress, chronic pain, and addiction. To work towards more effective treatments for these disorders, the laboratory is developing new technology to overcome existing limitations for accessing the nervous system. Nature Protocols pharmacology and optogenetics, which was published in and Matthew P. Haney is a graduate student in the Electrical, Computer, and Energy Engineering department at the University of Colorado Boulder. He received his BS degree in electrical engineering from the same institution in 2017 with focus on nano/micro materials and fabrication. He works and studies in Dr. Jae-Woong Jeong's research laboratory, where he specializes in the fabrication and characterization of soft biomedical devices. Dr. Jeong's research laboratory focuses on the development of next-generation soft biomedical devices for fundamental neuroscience research and various clinical applications. in vivo Dr. Sung Il Park is an Assistant Professor at Texas A&M. Park earned his PhD in electrical engineering from Stanford University. His expertise is in soft neural interface, low power analog circuits, high frequency RF circuit and antenna, and wireless power/communications systems. He has served as a peer reviewer for Applied Physics Letters, IEEE Transaction on Biomedical Engineering and Progress in Electromagnetics Research. His recent work on soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics has been featured in Nature Biotechnology and several news agencies. Dr. Jae-Woong Jeong is an Assistant Professor in Electrical, Computer, and Energy Engineering and Materials Science and Engineering Program at the University of Colorado Boulder. He received his BS degree from the University of Texas at Austin and his MS and PhD degrees from Stanford University, all in electrical engineering. He is an inventor of the wireless optofluidic neural systems for Cell ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
| ISSN: | 1473-0197 1473-0189 |
| DOI: | 10.1039/c7lc00103g |