Cloning, expression and functional characterization of recombinant tumor necrosis factor α1 (TNFα1) from white crucian carp in gut immune regulation

• Published in: International journal of biological macromolecules Vol. 254; no. Pt 1; p. 127770
• Main Authors: Li, Shi-Yun, Xiong, Ning-Xia, Li, Ke-Xin, Huang, Jin-Fang, Ou, Jie, Wang, Fei, Huang, Ming-Zhu, Luo, Sheng-Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2024
• Subjects: Aeromonas hydrophila; Antioxidant; antioxidants; atrophy; Carassius; caspases; Crucian carp; edema; farmed fish; homeostasis; Immune regulation; immunomodulation; lipopolysaccharides; midgut; mucins; mucosal immunity; pathogenesis; pleiotropy; superfamily; tight junctions; TNFα; tumor necrosis factors; Crucian carp; TNFα; Immune regulation; Antioxidant

TNFα is one of important cytokines belonging to TNF superfamily, which can exhibit a pleiotropic effect in immune modulation, homeostasis as well as pathogenesis. However, its immunoregulatory function on mucosal immunity in fish gut are still unclear. In this study, we aimed to investigated the imm...