Comparison of Biochemical Effects Induced by Changle between Male and Female Rats Using NMR and ICP-MS Techniques
Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle （A kind of rare earth complex applied in agriculture to raise the production of crops） at dose of 2, 5 and 20 mg·kg^-1 body weight/day respe...
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| Published in | Journal of rare earths Vol. 24; no. 1; pp. 108 - 114 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.02.2006
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1002-0721 2509-4963 |
| DOI | 10.1016/S1002-0721(06)60075-6 |
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| Abstract | Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle （A kind of rare earth complex applied in agriculture to raise the production of crops） at dose of 2, 5 and 20 mg·kg^-1 body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from ^1H NMR spectra and the contents of the four rare earth elements （La, Ce, Pr and Nd） constituting Changle in the serum samples are measured by ICP-MS technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethyglycine, dimethylamine, succinate, α- ketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum. |
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| AbstractList | O657.2%O614.3; Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle (A kind of rare earth complex applied in agriculture to raise the production of crops) at dose of 2, 5 and 20 mg*kg-1 body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from 1H NMR spectra and the contents of the four rare earth elements (La, Ce, Pr and Nd) constituting Changle in the serum samples are measured by ICP-MS technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethyglycine, dimethylamine, succinate, α-ketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum. Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle (A kind of rare earth complex applied in agriculture to raise the production of crops) at dose of 2, 5 and 20 mg*kg(-1) body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from H NMR spectra and the contents of the four rare earth elements (La, Ce, Pr and Nd) constituting Changle in the serum samples are measured by ICP-MS technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N,N-dimethyglycine, dimethylamine, succinate, alpha-ketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum. Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle (A kind of rare earth complex applied in agriculture to raise the production of crops) at dose of 2, 5 and 20 mg·kg −1 body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from 1H NMR spectra and the contents of the four rare earth elements (La, Ce, Pr and Nd) constituting Changle in the serum samples are measured by ICP-MS technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethyglycine, dimethylamine, succinate, α-ketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum. Metabolic profiles caused by rare earth complex were investigated using NMR and ICP-MS techniques. Male and female Wistar rats were treated orally with Changle （A kind of rare earth complex applied in agriculture to raise the production of crops） at dose of 2, 5 and 20 mg·kg^-1 body weight/day respectively for 90 d. Urine and serum samples are collected on 90 d. The relative concentrations of important endogenous metabolites in urine and serum are determined from ^1H NMR spectra and the contents of the four rare earth elements （La, Ce, Pr and Nd） constituting Changle in the serum samples are measured by ICP-MS technique. Changle-induced renal and liver damage in rats is found based on the increase in the amounts of the amino acids, trimethylamine N-oxide, N, N-dimethyglycine, dimethylamine, succinate, α- ketoglutarate and ethanol as well as rare earth concentrations. The similarities and differentiations are found in the alteration patterns of metabolites and rare earth concentrations in serum. |
| Author | 吴惠丰 李晓晶 冯江华 李伟生 李中峰 廖沛球 吴亦洁 裴奉奎 |
| AuthorAffiliation | Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China |
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| CitedBy_id | crossref_primary_10_1007_s12011_010_8698_x crossref_primary_10_1016_j_ecoenv_2020_111126 crossref_primary_10_3390_ijerph13030350 crossref_primary_10_1016_S1002_0721_06_60124_5 crossref_primary_10_1186_s12906_020_03067_3 crossref_primary_10_1139_er_2020_0115 crossref_primary_10_1007_s12598_015_0511_8 crossref_primary_10_1016_S1002_0721_08_60234_3 crossref_primary_10_1007_s12011_011_9193_8 crossref_primary_10_1016_j_chemosphere_2015_01_055 |
| Cites_doi | 10.1007/s002040050144 10.1021/ac960582w 10.1016/0079-6565(89)80008-1 10.1016/S0731-7085(97)00066-6 10.1139/y76-126 10.1002/(SICI)1099-1492(199806/08)11:4/5<235::AID-NBM507>3.0.CO;2-V 10.1021/ac00150a025 10.1021/ac00108a037 10.1016/S0079-6565(00)00036-4 10.1006/abio.2001.5471 10.1039/B109660P 10.1002/cjoc.20040220817 |
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| Title | Comparison of Biochemical Effects Induced by Changle between Male and Female Rats Using NMR and ICP-MS Techniques |
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