Amelioration of obesity and inflammation by polysaccharide from unripe fruits of raspberry via gut microbiota regulation

Raspberry, a traditional medicine food homology species, has important benefits in patients with metabolic syndrome. However, the mechanism of raspberry polysaccharides (RP) on obesity remains unclear. In our study, we showed that RP intervention is negatively associated with body weight gain, hyper...

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Published inInternational journal of biological macromolecules Vol. 261; no. Pt 2; p. 129825
Main Authors Huang, Yuzhe, Hu, Jingjing, Xia, Qijun, Tang, Maomao, Wang, Yuxiao, Wang, Guichun, Shao, Xinyuan, Yuan, Hao, Li, Shuhan, Huang, Peng, Peng, Chengjun, Guo, Jian, Gui, Shuangying
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2024
Subjects
bacteria
Bifidobacterium pseudolongum
body weight changes
colon
dysbiosis
endotoxemia
Gut microbiota
hyperlipidemia
Inflammation
Intestinal barrier function
intestinal microorganisms
Lactobacillus
lipopolysaccharides
metabolic syndrome
Obesity
prebiotics
raspberries
Raspberry polysaccharide
species
therapeutics
tight junctions
traditional medicine
Gut microbiota
Raspberry polysaccharide
Obesity
Inflammation
Intestinal barrier function
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Summary:Raspberry, a traditional medicine food homology species, has important benefits in patients with metabolic syndrome. However, the mechanism of raspberry polysaccharides (RP) on obesity remains unclear. In our study, we showed that RP intervention is negatively associated with body weight gain, hyperlipidemia, inflammation, and fat accumulation in obese mice. RP ameliorated HFD-induced gut microbiota dysbiosis, produced short-chain fatty acids, maintained intestinal barrier integrity, and prevented metabolic endotoxemia, manifested by decreased host lipopolysaccharide level, and increased colon expression of tight junction proteins. These effects might be related with driven by a SCFAs-producing bacterium and downregulation of TLR4/NF-κB signaling transduction. Notably, the abundance of Ruminococcaceae_UCG − 014, Lactobacillus taiwanensis, Bifidobacterium pseudolongum, and Turicibacter are markedly correlated with enhanced intestinal barrier function induced by RP treatment. Thus, we believe that RP could be as a potential health supplement or prebiotic for obesity therapy.
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ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.129825