Metal-polyphenol-coordinated nanomedicines for Fe(II) catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer

• Published in: Chinese chemical letters Vol. 33; no. 4; pp. 1895 - 1900
• Main Authors: Yu, Xinying, Shang, Tongyi, Zheng, Guodong, Yang, Hailong, Li, Yuwei, Cai, Yanjun, Xie, Guoxi, Yang, Bin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.04.2022; The Sixth Affiliated Hospital,Department of Biomedical Engineering,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China
• Subjects: Fenton reaction; Ferroptosis; Metal-polyphenol nanomedicines; Mild hyperthermia; Photoacoustic imaging; Metal-polyphenol nanomedicines; Ferroptosis; Fenton reaction; Photoacoustic imaging; Mild hyperthermia
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2021.10.021

Ferroustherapy has gained great attention for anti-cancer treatment in recent years. Enlightened by temperature-mediated Fenton reaction in industrial waste water removal, we designed a iron-based polyphenol-coordinated nanomedicines for mild hyperthermia-assisted anti-cancer ferroustherapy. In brief, Fe-GA@BSA nanoparticles was synthesized by self-assembly and sorafenib (SRF) was loaded into Fe-GA@BSA to establish Fe-GA@BSA-SRF nanomedicines. The result nanomedicines can induce ferroptosis in cancer cells by accelerating Fenton reaction. And the photothermal effect of Fe-GA@BSA-SRF was used for mild hyperthermia-assisted ferroustherapy. The nanomedicines performs good anti-cancer therapeutic efficacy by inducing the production of ROS and inhibiting glutathione peroxidase 4 (GPX4) expression in vitro and in vivo. Besides, the broad absorption of Fe-GA@BSA-SRF in near infrared region endows it with photoacoustic imaging ability. This study provides ideas about rational design on iron-based nanoparticles for anti-cancer ferroustherapy. [Display omitted] Metal-polyphenol-coordinated nanomedicine Fe-GA@BSA-SRF was established by self-assembly and drug loading. Fe-GA@BSA-SRF showed photoacoustic imaging ability and mild hyperthermia-assisted ferroustherapy.