Frequency of RAS and p53 mutations in acute promyelocytic leukemias

The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It wo...

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Bibliographic Details
Published inLeukemia & lymphoma Vol. 11; no. 5-6; p. 405
Main Authors Longo, L, Trecca, D, Biondi, A, Lo Coco, F, Grignani, F, Maiolo, A T, Pelicci, P G, Neri, A
Format Journal Article
LanguageEnglish
Published United States 1993
Subjects
Base Sequence
Genes, p53
Genes, ras
Humans
Leukemia, Promyelocytic, Acute - etiology
Leukemia, Promyelocytic, Acute - genetics
Molecular Sequence Data
Mutation
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Summary:The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.
ISSN:1042-8194
DOI:10.3109/10428199309067933