An experimental model for tympanosclerosis. A preliminary report

This study deals with an animal model where tympanosclerosis could be evoked with high reproducibility during the course of a sterile otitis media, induced by Eustachian tube obstruction. The histopathological features of this induced lesion were very similar to those reported in human specimens. It...

Full description

Saved in:
Bibliographic Details
Published inActa oto-laryngologica Vol. 105; no. 5-6; p. 537
Main Authors Wielinga, E W, Kuijpers, W, Tonnaer, E L, Jap, P H
Format Journal Article
LanguageEnglish
Published England 1988
Subjects
Animals
Germ-Free Life
Microscopy, Electron
Otitis Media with Effusion - pathology
Rats
Rats, Inbred Strains
Sclerosis
Tympanic Membrane - pathology
Online AccessGet more information

Cover

More Information
Summary:This study deals with an animal model where tympanosclerosis could be evoked with high reproducibility during the course of a sterile otitis media, induced by Eustachian tube obstruction. The histopathological features of this induced lesion were very similar to those reported in human specimens. It was concluded that this process is most probably triggered by a mechanical deformation of the tympanic membrane.
ISSN:0001-6489
DOI:10.3109/00016488809119516