Crystals in a jugulotympanic paraganglioma

The morphologic features of a jugulotympanic paraganglioma are reported. The tumor showed the usual histology of paragangliomas. No sustentacular cells were identified. In the tumorous chief cells there were typical neurosecretory dense-core granules 60-180 nm in diameter. Granules averaging 400 nm...

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Bibliographic Details
Published inUltrastructural pathology Vol. 10; no. 3; p. 257
Main Authors Horváth, K K, Ormos, J, Ribári, O
Format Journal Article
LanguageEnglish
Published England 1986
Subjects
Crystallization
Cytoplasmic Granules - ultrastructure
Ear Neoplasms - ultrastructure
Ear, Middle
Female
Humans
Inclusion Bodies - ultrastructure
Microscopy, Electron
Middle Aged
Paraganglioma - ultrastructure
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Summary:The morphologic features of a jugulotympanic paraganglioma are reported. The tumor showed the usual histology of paragangliomas. No sustentacular cells were identified. In the tumorous chief cells there were typical neurosecretory dense-core granules 60-180 nm in diameter. Granules averaging 400 nm in diameter were also observed, sometimes with a regular rhomboid core or crystallized content. Rhomboid crystals were seen in the cytoplasm in membrane-bound spaces and in telolysosomes. The crystals had a substructure consisting of alternating light and dark lines with a periodocity of 5-10 nm. Such crystals had not been reported previously in paragangliomas. The possible origin of the crystals is discussed.
ISSN:0191-3123
1521-0758
DOI:10.3109/01913128609032225