Chitosan capped copper oxide/copper nanoparticles encapsulated microbial resistant nanocomposite films

• Published in: International journal of biological macromolecules Vol. 128; pp. 499 - 508
• Main Authors: Jayaramudu, Tippabattini, Varaprasad, Kokkarachedu, Pyarasani, Radha D., Reddy, K. Koteshwara, Kumar, Kanderi Dileep, Akbari-Fakhrabadi, A., Mangalaraja, R.V., Amalraj, John
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019
• Subjects: antibiotics; antimicrobial properties; ascorbic acid; CHCu NPs; CHCuO NPs; chemical reduction; Chitosan; composite films; copper; copper nanoparticles; cupric oxide; Gram-positive bacteria; nanocomposites; sodium hydroxide; transmission electron microscopy; CHCu NPs; CHCuO NPs; Chitosan
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2019.01.145

Chitosan (CH) capped inorganic nanomaterials have been considered as significant antibacterial materials in the clinical field. This work shows the synthesis of two new different antibacterial composite films as a result of the incorporation of CH capped copper oxide (CHCuO) and copper (CHCu) nanoparticles (NPs). Here, CHCuO and CHCu NPs were achieved by a facile chemical reduction of Cu2+ ions using sodium hydroxide and ascorbic acid. TEM analysis revealed the morphology as rod-type nanoflakes for CHCuO and a spherical shape for CHCu NPs with ~7 ± 2 nm size. Antimicrobial activity of the developed materials was studied by the inhibition zone method, against both gram-negative and gram-positive bacteria. The antimicrobial activity revealed that the CHCuO NPs and CHCuO-CH film showed a higher inhibition zone than the other nanomaterials. The results suggested that the synthesized materials can be used in wound dressing applications. •Chitosan capped (CuO and Cu) nanoparticles were prepared by facile chemical reduction.•The CHCuO and CHCu NPs were blended with CH to form nanocomposite films by solution casting method•The CHCuO and their nanocomposite films showed better antimicrobial activity than other materials•Developed nanocomposite films will be useful for antimicrobial applications.