"How do adrenocortical steroid hormones produce hypertension?"

• Published in: Clinical and experimental hypertension. Part A, Theory and practice Vol. 6; no. 1-2; p. 315
• Main Authors: Scoggins, B A, Coghlan, J P, Denton, D A, Mills, E H, Nelson, M A, Spence, C D, Whitworth, J A
• Format: Journal Article
• Language: English
• Published: United States 1984
• Subjects: Adrenal Cortex Hormones - metabolism; Adrenal Cortex Hormones - pharmacology; Adrenocorticotropic Hormone - pharmacology; Animals; Blood Pressure - drug effects; Humans; Hypertension - chemically induced; Receptors, Glucocorticoid - metabolism; Sheep
• ISSN: 0730-0077
• DOI: 10.3109/10641968409062568

ACTH dependent and independent adrenocortical steroid hypertension in experimental animals is thought to be due to the 'mineralocorticoid' and/or 'glucocorticoid' activity of the steroid/s. Studies in sheep examining ACTH and adrenocortical steroid hypertension have provided evidence for a 'hypertensinogenic' class of steroid activity. A hypothesis is proposed to explain how the 'hypertensinogenic' actions of a steroid may produce hypertension. It is suggested that effects mediated via 'mineralocorticoid' and 'glucocorticoid' receptors may modulate or amplify the 'hypertensinogenic' activity. Individual steroids may express any, all or none of these three types of steroid hormone activity.