Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine

• Published in: Science (American Association for the Advancement of Science) Vol. 205; no. 4412; pp. 1272 - 1273
• Main Authors: Wimpfheimer, C, Saville, E, Voirol, M.J, Danforth, E. Jr, Burger, A.G
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 21.09.1979
• Subjects: animal experimentation; Animals; Body weight; Dose response relationship; Dose-Response Relationship, Drug; Energy Metabolism - drug effects; Hormone research; Hormones; Hypothyroidism - metabolism; Male; metabolic diseases; Metabolic regulation; Oxygen consumption; Oxygen Consumption - drug effects; Physiological aspects; Rats; Receptors, Cell Surface - drug effects; Starvation; Starvation - metabolism; Thermogenesis; Thyroid hormones; Triiodothyronine; Triiodothyronine - pharmacology

Since the activity of many hormones is not only dependent on the availability of the hormones, but also on the sensitivity of target tissues, a recent study examined this tissue sensitivity by measuring the change in oxygen consumption per minute per 100 grams of body weight during starvation. Earli...