Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine

Since the activity of many hormones is not only dependent on the availability of the hormones, but also on the sensitivity of target tissues, a recent study examined this tissue sensitivity by measuring the change in oxygen consumption per minute per 100 grams of body weight during starvation. Earli...

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Published inScience (American Association for the Advancement of Science) Vol. 205; no. 4412; pp. 1272 - 1273
Main Authors Wimpfheimer, C, Saville, E, Voirol, M.J, Danforth, E. Jr, Burger, A.G
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 21.09.1979
Subjects
animal experimentation
Animals
Body weight
Dose response relationship
Dose-Response Relationship, Drug
Energy Metabolism - drug effects
Hormone research
Hormones
Hypothyroidism - metabolism
Male
metabolic diseases
Metabolic regulation
Oxygen consumption
Oxygen Consumption - drug effects
Physiological aspects
Rats
Receptors, Cell Surface - drug effects
Starvation
Starvation - metabolism
Thermogenesis
Thyroid hormones
Triiodothyronine
Triiodothyronine - pharmacology
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Summary:Since the activity of many hormones is not only dependent on the availability of the hormones, but also on the sensitivity of target tissues, a recent study examined this tissue sensitivity by measuring the change in oxygen consumption per minute per 100 grams of body weight during starvation. Earlier studies confirmed that oxygen consumption decreases during caloric deprivation. Production of triiodothyroine in the thyroid also decreases. Studies on male Wistar rats conclude that starvation altered thyroid hormone activity by reducing effective serum concentrations of the hormone and by decreasing the body's response to the hormone.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.224460