Identification of Two Novel Peptides from the Central Nervous System of the Desert Locust,Schistocerca gregaria

From an acid methanolic extract of about 7000 brains of the desert locust (Schistocerca gregaria) two novel neuropeptides, schistomyotropin-1 (Scg-MT-1) and schistomyotropin-2 (Scg-MT-2), were isolated and identified. Their primary structures are GAAPAAQFSPRLamide (Scg-MT-1) and TSSLFPHPRLamide (Scg...

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Published inBiochemical and biophysical research communications Vol. 241; no. 2; pp. 530 - 534
Main Authors Veelaert, Dirk, Schoofs, Liliane, Verhaert, Peter, De Loof, Arnold
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 18.12.1997
Subjects
Animals
Biological Assay
CENTRAL NERVOUS SYSTEM
Central Nervous System - chemistry
Grasshoppers - chemistry
Muscles - drug effects
Neuropeptides - chemistry
Neuropeptides - pharmacology
PEPTIDE
PEPTIDES
PEPTIDOS
SCHISTOCERCA GREGARIA
Sequence Analysis
SISTEMA NERVIOSO CENTRAL
SYSTEME NERVEUX CENTRAL
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Summary:From an acid methanolic extract of about 7000 brains of the desert locust (Schistocerca gregaria) two novel neuropeptides, schistomyotropin-1 (Scg-MT-1) and schistomyotropin-2 (Scg-MT-2), were isolated and identified. Their primary structures are GAAPAAQFSPRLamide (Scg-MT-1) and TSSLFPHPRLamide (Scg-MT-2). Scg-MT-1 belongs to the locustamyotropin family characterized by its FXPRLamide C-terminus. Scg-MT-2 has a similar carboxyl end with the F-residue one position further away from the C-terminus. This may account for its being 10 times less active then Scg-MT-1 in stimulating cockroach hindgut motility.
Bibliography:1997091330
H10
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1997.7843