The effects of x-irradiation on collagen metabolism in rat skin

Collagen metabolism in rat skin and the response to X-radiation are studied during three consecutive hair-cycles. Collagen biosynthesis and turnover, assessed by the hydroxylation of [U-14C]-proline, proceeds as a function of the periodic hair-growth phenomenon. A single X-radiation treatment to the...

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Published inInternational journal of radiation biology and related studies in physics, chemistry and medicine Vol. 29; no. 4; p. 351
Main Authors De Loecker, W, Van der Schueren, E, Stas, M L, Doms, D
Format Journal Article
LanguageEnglish
Published England 01.01.1976
Subjects
Amino Acids - metabolism
Animals
Collagen - metabolism
Hair - physiology
Male
Radiation Effects
Rats
Rats, Inbred Strains
Skin - metabolism
Skin - radiation effects
X-Rays
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Summary:Collagen metabolism in rat skin and the response to X-radiation are studied during three consecutive hair-cycles. Collagen biosynthesis and turnover, assessed by the hydroxylation of [U-14C]-proline, proceeds as a function of the periodic hair-growth phenomenon. A single X-radiation treatment to the skin does not affect the amino-acid composition of collagen, but reduces the proline hydroxylation capacity of the fibroblasts. The initial damage to the tissue, resulting in a reduced collagen concentration of the skin, particularly noticeable after several hair-cycles, is at least partially responsible for the delayed skin lesions after irradiation.
ISSN:0020-7616
DOI:10.1080/09553007614550401