Bioreducible, hydrolytically degradable and targeting polymers for gene delivery
Recently, synthetic gene carriers have been intensively developed owing to their promising application in gene therapy and considered as a suitable alternative to viral vectors because of several benefits. But cationic polymers still face some problems like low transfection efficiency, cytotoxicity,...
Saved in:
| Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 5; no. 18; pp. 3253 - 3276 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
14.05.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | Recently, synthetic gene carriers have been intensively developed owing to their promising application in gene therapy and considered as a suitable alternative to viral vectors because of several benefits. But cationic polymers still face some problems like low transfection efficiency, cytotoxicity, and poor cell recognition and internalization. The emerging engineered and smart polymers can respond to some changes in the biological environment like pH change, ionic strength change and redox potential, which is beneficial for cellular uptake. Redox-sensitive disulfide based and hydrolytically degradable cationic polymers serve as gene carriers with excellent transfection efficiency and good biocompatibility owing to degradation in the cytoplasm. Additionally, biodegradable polymeric micelles with cell-targeting function are recently emerging gene carriers, especially for the transfection of endothelial cells. In this review, some strategies for gene carriers based on these bioreducible and hydrolytically degradable polymers will be illustrated.
Recently, synthetic gene carriers have been intensively developed owing to their promising application in gene therapy and considered as a suitable alternative to viral vectors because of several benefits. |
|---|---|
| Bibliography: | Jintang Guo received her PhD degree from Tianjin University in 1998. She is a Professor at Tianjin University. Her research focuses on functional biomaterials and gene delivery. Ihsan Ullah was born and raised in district Mardan, Pakistan. He received his Master's degree in organic chemistry from the Institute of Chemical Sciences, University of Peshawar, Pakistan. Then he obtained an M.Phil. Degree in organic chemistry from the Department of Chemistry, School of Science Abdul Wali Khan University Mardan in 2013. Now he is studying for a doctoral degree in the Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, P. R. China. His current research interest focuses on synthetic polymers for gene delivery. Changcan Shi received his MS degree from Hebei University in 2011, and his PhD degree from Tianjin University in 2014. He joined Wenzhou Institute of Biomaterials and Engineering (WIBE), CNITECH, CAS as an associate professor in July 2014. Now, he is the director of Joint Research Center for Medical Polymer Materials. His current research focuses on hemostatic materials and gene delivery. Yakai Feng received his BSc degree in Chemistry and MSc degree in Polymer Chemistry from Nankai University, and obtained his EngD in Organic Chemical Engineering from Tianjin University in 1997, and a PhD from RWTH Aachen University in 2000. He worked as a chemist in ADIAM life science AG and then in GKSS Research Center, Germany. Now he is a professor at Tianjin University. He is the director of Tianjin University-HZG Joint Laboratory for Biomaterials and Regenerative Medicine. His current research interests focus on surface modification, multifunctional materials and gene delivery. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2050-750X 2050-7518 |
| DOI: | 10.1039/c7tb00275k |