Catalytic, enantioselective vinylogous Michael reactions
Recent progress in the field of catalytic, enantioselective vinylogous Michael reactions of latent dienolates is described which furnish optically highly enriched chiral 1,7-dioxo compounds of great utility in one synthetic operation. Emphasis is given to new catalysis modes which realise this chall...
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| Published in | Organic & biomolecular chemistry Vol. 12; no. 22; pp. 3531 - 3543 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
14.06.2014
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| Online Access | Get full text |
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| Summary: | Recent progress in the field of catalytic, enantioselective vinylogous Michael reactions of latent dienolates is described which furnish optically highly enriched chiral 1,7-dioxo compounds of great utility in one synthetic operation. Emphasis is given to new catalysis modes which realise this challenging transformation with high regio- as well as enantioselectivity.
Recent progress towards catalytic, enantioselective vinylogous Michael reactions is presented which deliver optically highly enriched 1,7-dioxo compounds of great utility in organic synthesis. |
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| Bibliography: | Christoph Schneider earned his PhD degree in 1992 from the University of Göttingen for work in natural product synthesis with Prof. Lutz F. Tietze followed by a postdoctoral assignment with Prof. David A. Evans at Harvard University (USA). During 1994-1998 he completed his habilitation at the University of Göttingen during which time his group developed the silyloxy-Cope rearrangement of aldol products. Subsequently he was invited for visiting professorships to the University of Szeged (Hungary) in 1999 and the University of Toronto (Canada) in 2000. During 2001-2003 he had an appointment as an associate professor at the University of Saarbrücken and was appointed as a full professor at the University of Leipzig in 2003 where he has remained since then. His research interests are in the area of stereoselective synthesis with a special focus on catalytic enantioselective methods and their application in natural product synthesis. Falko Abels studied chemistry at the University of Leipzig and at Monash University, Melbourne. He earned his master of science degree in 2009 from the University of Leipzig for work on organocatalytic access toward tetrahydropyridines. After a short internship with Merck, Darmstadt, he completed his PhD thesis in the Schneider research group (2010-2013) on indolizidine and quinolizidine synthesis with a scholarship from Evonik Industries. In January 2014 he joined BASF (Ludwigshafen). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1477-0520 1477-0539 |
| DOI: | 10.1039/c4ob00332b |