Hepatitis C among child transfusion and adult renal dialysis patients in Indonesia

• Published in: The American journal of tropical medicine and hygiene Vol. 66; no. 3; pp. 317 - 320
• Main Authors: CHANPONG, G. Fraser, LARAS, Kanti, ALI SULAIMAN, H, SOEPRAPTO, Widodo, PURNAMAWATI, S, SUKRI, Nono, SIE, Annie, TAN, Ratna, CAMPBELL, James R, CORWIN, Andrew L
• Format: Journal Article
• Language: English
• Published: Lawrence, KS Allen Press 01.03.2002
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Hepacivirus - immunology; Hepatitis C - epidemiology; Hepatitis C Antibodies - blood; Human viral diseases; Humans; Indonesia - epidemiology; Infant; Infectious diseases; Male; Medical sciences; Middle Aged; Prevalence; Renal Dialysis - adverse effects; Risk Factors; Surveys and Questionnaires; Transfusion Reaction; Viral diseases; Viral hepatitis; Asia; Indonesia; Human; Prevalence; Transfusion; Hemodialysis; Hepatic disease; Epidemiology; Kidney; Blood; Infection; Extrarenal dialysis; Viral disease; Risk factor; Digestive diseases; Adult; Child; Viral hepatitis C
• ISSN: 0002-9637; 1476-1645
• DOI: 10.4269/ajtmh.2002.66.317

Hepatitis C virus (HCV) prevalence among high-risk pediatric and adult patients was evaluated. The study included 269 adults and 150 children in a case-control research design. Risk factors of HCV exposure in Indonesia were assessed among adult renal dialysis patients and pediatric patients who received multiple blood transfusions. A high prevalence of anti-HCV was found among the adult renal dialysis patients, measured by second-generation electroimmunoassay tests. Family members of dialysis patients, who served as a comparison group for dialysis patients, were found to have a 9.0% seroprevalence. The prevalence of anti-HCV among pediatric patients with hematological disorders was found to be 39.0%. The comparison group seroprevalence (pediatric patients and family members) was 4.3% among sera available for confirmatory testing. Patients with history of hospitalization (odds ratio [OR] = 7.94, 95% confidence interval [CI]: 4.06-15.51, P = 0.0001), blood transfusion (OR = 6.85, 95% CI: 3.95-11.88, P = 0.0001), circumcision (OR = 2.39, 95% CI: 1.43-3.99, P = 0.0001), or marital partner/family member history of jaundice (OR = 3.62, 95% CI: 1.97-6.62, P = 0.0001) were found to have an increased odds of HCV exposure compared with individuals without similar histories.