The renin-angiotensin-aldosterone system in rats of both sexes subjected to chronic hypobaric hypoxia

Plasma renin activity (PRA), plasmatic aldosterone, haematocrit, haemoglobin concentration and plasma proteins were measured in 36 Wistar rats of both sexes submitted to 380 mmHg in hypopressure chamber during 7 months and in a group of control animals (15 male and 15 female rats). PRA was significa...

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Bibliographic Details
Published inArchives internationales de physiologie et de biochimie Vol. 90; no. 3; p. 129
Main Authors Martín, I H, Baulán, D, Basso, N, Taquini, A C
Format Journal Article
LanguageEnglish
Published Belgium 01.01.1982
Subjects
Aldosterone - blood
Animals
Female
Hematocrit
Hemoglobins - analysis
Hypoxia - physiopathology
Male
Rats
Rats, Inbred Strains
Renin - blood
Renin-Angiotensin System
Sex Factors
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Summary:Plasma renin activity (PRA), plasmatic aldosterone, haematocrit, haemoglobin concentration and plasma proteins were measured in 36 Wistar rats of both sexes submitted to 380 mmHg in hypopressure chamber during 7 months and in a group of control animals (15 male and 15 female rats). PRA was significantly increased in hypoxic male (P less than 0.05) and female (P less than 0.01) rats. On the contrary, plasma aldosterone concentration did not show any significant variation. There thus was a clear dissociation between the plasmatic renin-angiotensin system and the aldosterone in rats of both sexes submitted to severe chronic hypobaric hypoxia.
ISSN:0003-9799
DOI:10.3109/13813458209070562