Thyroid-hormone control of state-3 respiration in isolated rat liver mitochondria

Oxidative phosphorylation can be treated as two groups of reactions; those that generate protonmotive force (dicarboxylate carrier, succinate dehydrogenase and the respiratory chain) and those that consume protonmotive force (adenine nucleotide and phosphate carriers. ATP synthase and proton leak)....

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Published inBiochemical journal Vol. 265; no. 3; pp. 731 - 734
Main Authors Hafner, R P, Brown, G C, Brand, M D
Format Journal Article
LanguageEnglish
Published England 01.02.1990
Subjects
Animals
Hypothyroidism - metabolism
Kinetics
mitochondria
Mitochondria, Liver - metabolism
Oxidative Phosphorylation
Oxygen Consumption
Rats
respiration
thyroid hormones
Thyroid Hormones - physiology
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Summary:Oxidative phosphorylation can be treated as two groups of reactions; those that generate protonmotive force (dicarboxylate carrier, succinate dehydrogenase and the respiratory chain) and those that consume protonmotive force (adenine nucleotide and phosphate carriers. ATP synthase and proton leak). Mitochondria from hypothyroid rats have lower rates of respiration in the presence of ADP (state 3) than euthyroid controls. We show that the kinetics of the protonmotive-force generators are unchanged in mitochondria from hypothyroid animals, but the kinetics of the protonmotive-force consumers are altered, supporting proposals that the important effects of thyroid hormone on state 3 are on the ATP synthase or the adenine nucleotide translocator.
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ISSN:0264-6021
1470-8728
DOI:10.1042/bj2650731