Bovine serum conglutinin is a lectin which binds non-reducing terminal N-acetylglucosamine, mannose and fucose residues

Carbohydrate recognition by bovine serum conglutinin has been investigated by inhibition and direct binding assays using glycoproteins and polysaccharides from Saccharomyces cerevisiae (baker's yeast), and neoglycolipids derived from N-acetylglucosamine oligomers, mannobiose and human milk olig...

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Bibliographic Details
Published inBiochemical journal Vol. 258; no. 1; pp. 109 - 113
Main Authors Loveless, R W, Feizi, T, Childs, R A, Mizuochi, T, Stoll, M S, Oldroyd, R G, Lachmann, P J
Format Journal Article
LanguageEnglish
Published England 15.02.1989
Subjects
Acetylglucosamine - metabolism
Animals
Binding Sites
carbohydrates
Cattle
Collectins
Complement Fixation Tests
Disaccharides
Fucose - metabolism
Glucans - metabolism
Glucosamine - analogs & derivatives
Lectins - metabolism
Mannans - metabolism
Mannose - metabolism
Oligosaccharides - metabolism
Saccharomyces cerevisiae
Serum Globulins - metabolism
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Summary:Carbohydrate recognition by bovine serum conglutinin has been investigated by inhibition and direct binding assays using glycoproteins and polysaccharides from Saccharomyces cerevisiae (baker's yeast), and neoglycolipids derived from N-acetylglucosamine oligomers, mannobiose and human milk oligosaccharides. The results clearly show that conglutinin is a lectin which binds terminal N-acetylglucosamine, mannose and fucose residues as found in chitobiose (GlcNAc beta 1-4GlcNAc), mannobiose (Man alpha 1-3Man) and lacto-N-fucopentaose II [Fuc alpha 1-4(Gal beta 1-3)GlcNAc beta 1-3Gal beta 1-4Glc] respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0264-6021
1470-8728
DOI:10.1042/bj2580109