The influence of poly(ethylene glycol) 6000 on spermine-induced aggregation of liposomes

Poly(ethylene glycol) 6000 affected the aggregation of mixed liposomes induced by spermine. It lowered the concentration of spermine causing 50% maximal aggregation, accelerated the rate and increased the extent of aggregation. The effect was inversely proportional to the density of the acidic phosp...

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Bibliographic Details
Published inBiochemical journal Vol. 236; no. 3; pp. 651 - 655
Main Authors Tadolini, B, Varani, E, Cabrini, L
Format Journal Article
LanguageEnglish
Published England 15.06.1986
Subjects
Drug Synergism
liposomes
Liposomes - metabolism
Macromolecular Substances
Phospholipids - metabolism
polyethylene glycol
Polyethylene Glycols - pharmacology
Spermine - pharmacology
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Summary:Poly(ethylene glycol) 6000 affected the aggregation of mixed liposomes induced by spermine. It lowered the concentration of spermine causing 50% maximal aggregation, accelerated the rate and increased the extent of aggregation. The effect was inversely proportional to the density of the acidic phospholipid in the vesicles. These effects were not due either to poly(ethylene glycol) 6000-induced permanent structural modification of the liposome or increased binding of spermine to the vesicles. These findings are discussed in relation to a decreased hydration force caused by the ability of poly(ethylene glycol) 6000 to alter the water of hydration of the phospholipid polar groups in the liposome.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2360651