Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions

• Published in: Caries research Vol. 51; no. 6; pp. 590 - 595
• Main Authors: Kastovsky, Jakub, Borilova Linhartova, Petra, Musilova, Kristina, Zackova, Lenka, Kukletova, Martina, Kukla, Lubomir, Izakovicova Holla, Lydie
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2017
• Subjects: Adolescent; Alleles; Analysis; Bone Morphogenetic Protein 2 - genetics; Bone morphogenetic proteins; Child; Child, Preschool; Czech Republic; Dental caries; Dental Caries - genetics; Dentistry; Dentition, Permanent; DMF Index; Female; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype; Homeodomain Proteins - genetics; Humans; Male; Polymorphism, Single Nucleotide; Severity of Illness Index; Short Communication; Tooth, Deciduous; Transcription Factors - genetics; Czech Republic; Dental caries; Case-control study; BMP2; DLX3; Gene polymorphism
• ISSN: 0008-6568; 1421-976X
• DOI: 10.1159/000479828

The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT ≥1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft ≥1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT ≥9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population.