Ultrasound-assisted synthesis of MIL-88(Fe) coordinated to carboxymethyl cellulose fibers: A safe carrier for highly sustained release of tetracycline

• Published in: International journal of biological macromolecules Vol. 181; pp. 937 - 944
• Main Authors: Darvishi, Sima, Javanbakht, Siamak, Heydari, Abolfazl, Kazeminava, Fahimeh, Gholizadeh, Pourya, Mahdipour, Mahdi, Shaabani, Ahmad
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.06.2021
• Subjects: antibacterial properties; aqueous solutions; bacterial infections; Carboxymethylcellulose; Controlled release; cytotoxicity; drug carriers; Escherichia coli; fibroblasts; Metal-organic framework; skin (animal); Tetracycline; toxicity testing; ultrasonic treatment; Ultrasound; Metal-organic framework; Carboxymethylcellulose; Ultrasound; Controlled release; Tetracycline
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2021.04.092

For stopping long-time harmful bacterial infection, designing a drug carrier with a highly prolonged release profile is a promising approach that is of interest to different biomedical areas. The subject of this work is to synthesis a novel carrier system through coordination of MIL-88(Fe) to carboxymethyl cellulose (CMC) for enhancing interaction between drug and carrier. We established an ultrasound-assisted synthetic method for in situ synthesis of MIL-88(Fe) in the presence of CMC resulting in CMC/MIL-88(Fe) composite. The CMC/MIL-88(Fe) was loaded with a high amount of Tetracycline (TC) by immersion of carrier to the TC aqueous solution. The release profile in the simulated physiological conditions, pH 7.4, revealed a low initial burst release followed by a sustained and prolonged release over 384 h. The in vitro cytotoxicity of CMC/MIL-88(Fe) against Human skin fibroblast (HFF-1) cells was calculated by MTT assay and showed a good cytocompatibility. The antibacterial activity was found for TC-loaded CMC/MIL-88(Fe) toward both E. coli and S. aureus with MIC 64 mg·ml−1.