Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-A, skeletal muscle isoenzyme

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human p...

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Bibliographic Details
Published inCancer investigation Vol. 6; no. 1; p. 93
Main Authors Li, S S, Pan, Y E, Sharief, F S, Evans, M J, Lin, M F, Clinton, G M, Holbrook, J J
Format Journal Article
LanguageEnglish
Published England 1988
Subjects
Amino Acid Sequence
Animals
Biomarkers, Tumor - analysis
Humans
Isoenzymes
L-Lactate Dehydrogenase - analysis
Molecular Sequence Data
Muscles - enzymology
Neoplasms - diagnosis
Neoplasms - enzymology
Species Specificity
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Summary:Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.
ISSN:0735-7907
DOI:10.3109/07357908809077032