Characterization and pharmacological studies of an octopamine-sensitive adenylate cyclase from nerve cord of Locusta migratoria

An octopamine-sensitive adenylate cyclase that is insensitive to stimulation by dopamine (DA) and 5-hydroxytryptamine (5-HT), was studied in a homogenized nerve cord preparation of the migratory locust, Locusta migratoria. The enzyme complex is similar to catecholamine-sensitive cyclases from mammal...

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Bibliographic Details
Published inArchives internationales de physiologie, de biochimie et de biophysique Vol. 99; no. 2; p. 189
Main Authors Wang, Z W, Downer, R G, Gole, J W, Orr, G L
Format Journal Article
LanguageEnglish
Published Belgium 1991
Subjects
Adenylyl Cyclases - drug effects
Animals
Colforsin - pharmacology
Cyclic AMP - metabolism
Dopamine - pharmacology
Grasshoppers - drug effects
Grasshoppers - enzymology
In Vitro Techniques
Male
Nerve Fibers - drug effects
Nerve Fibers - enzymology
Octopamine - pharmacology
Serotonin - pharmacology
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Summary:An octopamine-sensitive adenylate cyclase that is insensitive to stimulation by dopamine (DA) and 5-hydroxytryptamine (5-HT), was studied in a homogenized nerve cord preparation of the migratory locust, Locusta migratoria. The enzyme complex is similar to catecholamine-sensitive cyclases from mammals with respect to pH-optimum, requirement for Mg++ and GTP, and sensitivity to forskolin. The octopamine-mediated elevation of adenylate cyclase activity is antagonized by a variety of drugs with the following order of potency: mianserin greater than phentolamine greater than promethazine greater than gramine greater than cyproheptadine greater than cis-flupenthixol greater than chlorpromazine greater than metoclopramide.
ISSN:0778-3124
DOI:10.3109/13813459109146962