Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus

• Published in: The journal of clinical endocrinology and metabolism Vol. 94; no. 1; pp. 45 - 49
• Main Authors: Kanazawa, Ippei, Yamaguchi, Toru, Yamamoto, Masahiro, Yamauchi, Mika, Kurioka, Soichi, Yano, Shozo, Sugimoto, Toshitsugu
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.01.2009
• Subjects: Aged; Aged, 80 and over; Alkaline Phosphatase - blood; Atherosclerosis - blood; Biological and medical sciences; Calcium-Binding Proteins - blood; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Extracellular Matrix Proteins - blood; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glucose - metabolism; Humans; Male; Matrix Gla Protein; Medical sciences; Middle Aged; Osteocalcin - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Endocrinopathy; Type 2 diabetes; Obesity; Osteocalcin; Nutrition; Nutrition disorder; Cardiovascular disease; Metabolic diseases; Glucose; Metabolism; Vascular disease; Association; Atherosclerosis; Clinical biology; Endocrinology; Nutritional status
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2008-1455

Context: Recent animal studies showed that osteocalcin action is related to not only bone metabolism but also glucose metabolism and fat mass. We investigated the relationship between two bone formation markers, serum osteocalcin and bone-specific alkaline phosphatase, and glucose metabolism, serum adiponectin, and the amount of fat mass as well as atherosclerosis parameters in men and postmenopausal women with type 2 diabetes. Methods: A total of 179 men and 149 postmenopausal women were recruited consecutively, and radiographic and biochemical characteristics were collected. Brachial-ankle pulse wave velocity (baPWV) and intima-media thickness (IMT) were evaluated as the parameters of atherosclerosis. Results: Multiple regression analysis adjusted for age, duration of diabetes, body mass index, and serum creatinine showed that osteocalcin negatively correlated with fasting plasma glucose and hemoglobin A1c in both men and postmenopausal women (P < 0.05) and with percent fat, baPWV, and IMT in men (P < 0.05). Osteocalcin positively correlated with total adiponectin in postmenopausal women (P < 0.001). After additional adjustments for systolic blood pressure, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, hemoglobin A1c, and Brinkmann index, osteocalcin still significantly and negatively correlated with baPWV and IMT in men. In contrast, osteocalcin did not correlate with fasting C-peptide, and bone-specific alkaline phosphatase did not correlate with any variable in either men or postmenopausal women. Conclusions: Serum osteocalcin is associated with glucose and total adiponectin levels, fat mass, and atherosclerosis parameters in patients with type 2 diabetes, suggesting that osteocalcin is important for not only bone metabolism but also glucose and fat metabolism. Serum osteocalcin is associated with glucose and serum adiponectin levels, fat mass, and atherosclerosis parameters in patients with type 2 diabetes. Thus, osteocalcin is important for not only bone metabolism, but also glucose and fat metabolism.