Photodynamic therapy based on organic small molecular fluorescent dyes

• Published in: Chinese chemical letters Vol. 30; no. 10; pp. 1689 - 1703
• Main Authors: Li, Li, Chen, Yisha, Chen, Weijie, Tan, Ying, Chen, Haiyan, Yin, Jun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2019; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China; Department of Biomedical Engineering, School of Engineering, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China%Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent BiosensingTechnology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China%State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China%Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent BiosensingTechnology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China
• Subjects: BODIPY; Cyanine; Near-infrared fluorescent dyes; Photodynamic therapy; Phthalocyanine; Near-infrared fluorescent dyes; Phthalocyanine; BODIPY; Photodynamic therapy; Cyanine
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2019.04.017

This review aims to provide a summary of the progress in organic small molecular fluorescent dyes for photodynamic therapy in recent years and it is classified according to the structures of dyes including cyanines, phthalocyanine, BODIPYs and other agents. [Display omitted] Photodynamic therapy (PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared (NIR) fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues.