Distribution of captopril to foetuses and milk of rats

1. 14C-Captopril (50 mg/kg) administered orally to pregnant rats resulted in radioactivity passing the placental barrier into foetuses and amniotic fluid. Two hours after dosing, the mean (+/- S.E.M.) concentration of total radioactivity was 0.97 +/- 0.07 micrograms equiv. of captopril/g in foetuses...

Full description

Saved in:
Bibliographic Details
Published inXenobiotica Vol. 12; no. 10; p. 627
Main Authors Ita, C E, Singhvi, S M, Heald, A F, Migdalof, B H
Format Journal Article
LanguageEnglish
Published England 01.01.1982
Subjects
Animals
Autoradiography
Captopril - metabolism
Female
Maternal-Fetal Exchange
Milk - analysis
Placenta - metabolism
Pregnancy
Proline - analogs & derivatives
Rats
Online AccessGet more information

Cover

More Information
Summary:1. 14C-Captopril (50 mg/kg) administered orally to pregnant rats resulted in radioactivity passing the placental barrier into foetuses and amniotic fluid. Two hours after dosing, the mean (+/- S.E.M.) concentration of total radioactivity was 0.97 +/- 0.07 micrograms equiv. of captopril/g in foetuses and 7.8 +/- 0.54 micrograms equiv./g in maternal blood. The mean concentration of unchanged captopril at this time was 0.22 +/- 0.04 micrograms/g in foetuses and 2.4 +/- 0.27 micrograms/g in maternal blood. Results obtained by whole-body autoradiography generally were consistent with those obtained by measuring radioactivity in excised tissues. 2. Radioactivity was also found in suckling pups and in the milk of th dams. Autoradiographs of the pups showed detectable radioactivity in the brain; as no radioactivity was detectable in the brain of the dam, it appears that the blood-brain barrier was not fully developed in seven-day-old pups.
ISSN:0049-8254
DOI:10.3109/00498258209042041