Fentanyl overdoses and pharmacogenetics

Fentanyl has been implicated as a major contributor to the increased number of opioid overdose deaths. Surprisingly, little is known about the pharmacogenetic influences on fentanyl pharmacokinetics or pharmacodynamics. Pharmacogenetic studies of fentanyl are based largely on small sample sizes and...

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Bibliographic Details
Published inPharmacogenetics and genomics Vol. 30; no. 1; p. 5
Main Authors Gerhard, Glenn S, Kaniper, Scott, Paynton, Barbara
Format Journal Article
LanguageEnglish
Published United States 01.01.2020
Subjects
ATP Binding Cassette Transporter, Subfamily B - genetics
Catechol O-Methyltransferase - genetics
Drug Overdose - genetics
Fentanyl - adverse effects
Genetic Association Studies
Humans
Pharmacogenomic Variants
Polymorphism, Single Nucleotide
Receptors, Opioid, mu - genetics
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Summary:Fentanyl has been implicated as a major contributor to the increased number of opioid overdose deaths. Surprisingly, little is known about the pharmacogenetic influences on fentanyl pharmacokinetics or pharmacodynamics. Pharmacogenetic studies of fentanyl are based largely on small sample sizes and have examined the potential association of only a small number of high frequency variants in selected candidate genes primarily with postoperative pain. Few data are available on low frequency variants, variants from racially/ethnically diverse populations, or on other phenotypes. Given the genetic diversity of low frequency variants, DNA sequencing may be needed to determine whether pharmacogenetic differences may contribute to lethal opioid overdoses.
ISSN:1744-6880
DOI:10.1097/FPC.0000000000000389