Correlation of serum IGF-I and IGFBP-1 and -3 to cardiovascular risk indicators and early carotid atherosclerosis in healthy middle-aged men

• Published in: Clinical endocrinology (Oxford) Vol. 68; no. 1; pp. 51 - 58
• Main Authors: Boquist, S., Ruotolo, G., Skoglund-Andersson, C., Tang, R., Björkegren, J., Bond, M. G., De Faire, U., Brismar, K., Hamsten, A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2008; Blackwell
• Subjects: Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular Diseases - blood; Carotid Artery Diseases - blood; Carotid Intima-Media Thickness; Endocrinopathies; Fasting - blood; Fundamental and applied biological sciences. Psychology; Humans; Insulin-Like Growth Factor Binding Protein 1 - blood; Insulin-Like Growth Factor Binding Protein 3 - blood; Insulin-Like Growth Factor I - metabolism; Lipids - blood; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Postprandial Period; Risk Factors; Vertebrates: endocrinology; Human; Correlation; Middle age; Male; Cardiovascular disease; Insulin like growth factor binding protein 3; Insulin like growth factor 1; Artery; Indicator; Vascular disease; Insulin like growth factor binding protein; Insulin-like growth factor binding protein-3; Insulin like growth factor binding protein 1; Blood vessel; Carotid; Atherosclerosis; Risk factor; Cardiovascular risk; Adult; Early; Serum; Circulatory system; Endocrinology
• ISSN: 0300-0664; 1365-2265; 1365-2265
• DOI: 10.1111/j.1365-2265.2007.02998.x

Summary Objectives  IGF‐I, IGFBP‐1 and IGFBP‐3 are putative mediators in cardiovascular disease. The present study examined (i) the correlations of circulating IGF‐I, IGFBP‐1 and IGFBP‐3 to established cardiovascular risk factors and signs of early atherosclerosis as reflected by ultrasound measurement of common carotid intima–media thickness (IMT), and (ii) whether serum concentrations of these analytes are modulated during alimentary lipaemia. Design  Cross‐sectional clinical study. Patients  A biobank and clinical database based on 96 healthy Caucasian men, aged 50 years, with an apolipoprotein (apo) E3/E3 genotype, who had originally undergone investigations of postprandial lipoprotein metabolism was used for the study. Measurements  Total IGF‐I, IGFBP‐1 and IGFBP‐3 were determined in serum by radioimmunoassay (RIA). Free IGF‐I was measured by a commercial two‐site immunoradiometric assay (IRMA). Results  In multivariate analyses, fasting serum free IGF‐I correlated inversely with IMT and accounted for 5% of the variation in multiple R2. When fasting serum IGFBP‐1 was entered in the models instead of IGF‐I, IGFBP‐1 correlated positively with IMT and accounted for 6% of the variation in IMT. IGFBP‐3 and total IGF‐I were unrelated to IMT. There were no associations between free IGF‐I and cardiovascular risk factors, whereas IGFBP‐1 behaved like a component of the insulin resistance syndrome. Serum free IGF‐I increased and IGFBP‐1 decreased postprandially. Conclusion  The data indicate that serum free IGF‐I and IGFBP‐1 are implicated in early atherosclerosis.