Kudingcha and Fuzhuan Brick Tea Prevent Obesity and Modulate Gut Microbiota in High‐Fat Diet Fed Mice

• Published in: Molecular nutrition & food research Vol. 62; no. 6; pp. e1700485 - n/a
• Main Authors: Chen, Guijie, Xie, Minhao, Dai, Zhuqing, Wan, Peng, Ye, Hong, Zeng, Xiaoxiong, Sun, Yi
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2018
• Subjects: Abundance; Animals; Bacteroidetes; Beverages; Bifidobacteriaceae; C-Reactive Protein - analysis; China; Diet; Diet, High-Fat; Dietary supplements; Erysipelotrichaceae; fuzhuan brick tea; Gastrointestinal Microbiome; gut microbiota; High fat diet; Ilex; Ilex kaushue; inflammation; Injury prevention; Intestinal microflora; intestinal microorganisms; kudingcha; Lipid Metabolism; Liver - metabolism; Male; metabolic diseases; Metabolic disorders; Metabolic syndrome; Metabolism; Mice; Mice, Inbred C57BL; Microbiota; Obesity; Obesity - prevention & control; Oxidative metabolism; Relative abundance; Tea; China; kudingcha; fuzhuan brick tea; gut microbiota; obesity; high-fat diet
• ISSN: 1613-4125; 1613-4133; 1613-4133
• DOI: 10.1002/mnfr.201700485

Scope Kudingcha (KDC) from Ilex kudingcha and Fuzhuan brick tea (FBT) are popular beverages in China, and their preventive and therapeutic roles in metabolic disorders have been reported. However, the relationship between the gut microbiota modulatory effects of KDC and FBT and prevention of obesity is still not clearly understood. Methods and results KDC and FBT are tested individually for their capacities to prevent obesity and modulate the gut microbiota in high‐fat diet (HFD) fed C57BL/6J mice. The results show that both KDC and FBT supplementation could modulate oxidative injury, inflammation, lipid metabolism, and reduce HFD induced obesity significantly. Both KDC and FBT could enhance the diversity of gut microbiota. KDC could reduce the relative abundance of Erysipelotrichaceae, while FBT could reduce the ratio of Firmicutes to Bacteroidetes and enhance the relative abundance of Bifidobacteriaceae. Conclusion These findings suggest that KDC and FBT could attenuate features of the metabolic syndrome in HFD‐fed mice, which might be due to the modulation of gut microbiota by KDC and FBT. The relationship between the gut microbiota modulatory effects of Kudingcha (KDC) and Fuzhuan brick tea (FBT) and prevention of obesity is investigated in this work. The HFD‐induced dysbiosis of gut microbiota is reversed by the consumption of KDC and FBT, and the diversity of gut microbiota could be enhanced by KDC and FBT.