Reduced adherence of micro‐organisms to human mucosal epithelial cells following treatment with Taurolin, a novel antimicrobial agent

Taurolin, a non‐antibiotic antimicrobial agent, significantly reduced the adherence of buccal and vaginal strains of Candida albicans blastospores and urine isolates of Escherichia coli and Staphylococcus saprophyticus to epithelial cells. Light microscopy and radio‐isotopic counting methods were us...

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Bibliographic Details
Published inJournal of applied bacteriology Vol. 62; no. 4; pp. 315 - 320
Main Authors Gorman, S. P, McCafferty, D. F, Woolfson, A. D, Jones, D. S
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.04.1987
Subjects
Anti-Bacterial Agents
anti-infective agents
Anti-Infective Agents - pharmacology
Bacterial Adhesion - drug effects
blastospores
Candida albicans
Candida albicans - drug effects
Candida albicans - physiology
Cell Adhesion
Epithelial Cells
Epithelium - microbiology
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - physiology
Female
Humans
light microscopy
Male
microorganisms
Mouth Mucosa - microbiology
Staphylococcus - drug effects
Staphylococcus - physiology
Staphylococcus saprophyticus
Taurine - analogs & derivatives
Thiadiazines - pharmacology
Thiazines - pharmacology
Urinary Tract - microbiology
urine
Urine - cytology
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Summary:Taurolin, a non‐antibiotic antimicrobial agent, significantly reduced the adherence of buccal and vaginal strains of Candida albicans blastospores and urine isolates of Escherichia coli and Staphylococcus saprophyticus to epithelial cells. Light microscopy and radio‐isotopic counting methods were used to quantify the adherence of the micro‐organisms to either uroepithelial or buccal epithelial cells. A maximum reduction in adherence of approximately 65% was obtained. The anti‐adherence capacity was time‐dependent, requiring a contact time of 30 min to achieve maximum effect. Taurolin at sub‐minimum inhibitory concentrations (MIC) significantly reduced the adherence of Candida and E. coli. A concentration slightly higher than the MIC was required for Staph. saprophyticus. Treatment of either epithelial cells or micro‐organisms with Taurolin resulted in reduced adherence of microorganisms.
Bibliography:http://dx.doi.org/10.1111/j.1365-2672.1987.tb04926.x
ISSN:1364-5072
0021-8847
1365-2672
DOI:10.1111/j.1365-2672.1987.tb04926.x