Effect of clomiphene citrate upon periovulatory endometrial development in the baboon

Endometrial histology in baboons (Papio cynocephalus anubis) was evaluated after five days of clomiphene citrate (CC) treatment initiated on either cycle day six (n = 8) or ten (n = 4). Biopsies performed before and after a human chorionic gonadotropin (hCG) induced ovulation were compared to non-CC...

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Bibliographic Details
Published inJournal of medical primatology Vol. 20; no. 2; p. 49
Main Authors Eley, R M, Gould, K G, Eley, D S, Suleman, M A, Tarara, R P
Format Journal Article
LanguageEnglish
Published Denmark 01.02.1991
Subjects
Animals
Biopsy, Needle - veterinary
Clomiphene - pharmacology
Endometrium - drug effects
Endometrium - growth & development
Endometrium - ultrastructure
Female
Luteal Phase
Menstrual Cycle
Microscopy, Electron, Scanning
Ovulation
Papio - physiology
Perineum
Skin - drug effects
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Summary:Endometrial histology in baboons (Papio cynocephalus anubis) was evaluated after five days of clomiphene citrate (CC) treatment initiated on either cycle day six (n = 8) or ten (n = 4). Biopsies performed before and after a human chorionic gonadotropin (hCG) induced ovulation were compared to non-CC treated controls. Although CC had a definite antiestrogenic effect on perineal skin, no significant effect of endometrial proliferation was demonstrable.
ISSN:0047-2565
1600-0684
DOI:10.1111/j.1600-0684.1991.tb00492.x