Anti-inflammatory studies on Polygonum glabrum

Anti-inflammatory studies were conducted on a hot water decoction and on an ethanol extract of the stems of Polygonum glabrum. Effective anti-inflammatory activity was demonstrated against acute carrageenan-induced paw oedema, exudate and granuloma formation in the granuloma pouch test, acute and de...

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Bibliographic Details
Published inJournal of ethnopharmacology Vol. 19; no. 3; pp. 255 - 267
Main Authors Singh, B, Pandey, V.B, Joshi, V.K, Gambhir, S.S
Format Journal Article
LanguageEnglish
Published Ireland 01.05.1987
Subjects
Animals
Anti-Inflammatory Agents
Arthritis - chemically induced
Arthritis - prevention & control
Arthritis, Experimental - prevention & control
Edema - prevention & control
Ethanol
Female
Formaldehyde
Granuloma - drug therapy
Male
Medicine, Ayurvedic
Mice
plant extracts
Plant Extracts - pharmacology
Plant Extracts - toxicity
Polygonum
Rats
Time Factors
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Summary:Anti-inflammatory studies were conducted on a hot water decoction and on an ethanol extract of the stems of Polygonum glabrum. Effective anti-inflammatory activity was demonstrated against acute carrageenan-induced paw oedema, exudate and granuloma formation in the granuloma pouch test, acute and delayed reactions in formaldehyde arthritis, and acute primary and delayed secondary reactions in adjuvant-induced polyarthritis in albino rats. The acute toxicity in albino mice and 1-month studies on subacute toxicity in rats suggested a good margin of safety. The extract was more effective parenterally than by oral administration.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(87)90003-1