In Vitro Anti-oxidant Effect of Vitamin E on Oxidative Stress Induced due to Pesticides in Rat Erythrocytes

An attempt was made to study the antioxidant property of vitamin E in endosulfan and chlorpyrifos toxicity. Erythrocytes were collected from healthy rats and exposed to 1 ppm endosulfan and chlorpyrifos pesticides individually and also along with vitamin E treatment. Results showed that endosulfan w...

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Bibliographic Details
Published inToxicology international Vol. 18; no. 1; pp. 73 - 76
Main Authors Saxena, Ronika, Garg, Poonam, Jain, D K
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.01.2011
Medknow Publications & Media Pvt. Ltd
Medknow Publications
Subjects
Antioxidants
Care and treatment
Erythrocytes
Free radicals
Health aspects
Original
Oxidative stress
Pesticides
Physiological aspects
Risk factors
Rodents
Vitamin E
India
erythrocytes
Catalase
endosulfan
superoxide dismutase
vitamin E
chlorphyrifos
lipid peroxidation
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Summary:An attempt was made to study the antioxidant property of vitamin E in endosulfan and chlorpyrifos toxicity. Erythrocytes were collected from healthy rats and exposed to 1 ppm endosulfan and chlorpyrifos pesticides individually and also along with vitamin E treatment. Results showed that endosulfan was more toxic in comparison of chlorpyrifos. Activities of superoxide dismutase and catalase were significantly decreased, while lipid peroxidation and glutathione-S-transfarase were increased in comparison to the control values. The results of the present study suggest that vitamin E acts as an effective antioxidant for endosulfan and chlorpyrifos pesticide toxicity, in reducing oxidative stress burden.
ISSN:0971-6580
0976-5131
DOI:10.4103/0971-6580.75871