The Helix Twist: Damage and Repair Follows the DNA Minor Groove

Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair process...

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Bibliographic Details
Published inCell Vol. 175; no. 4; pp. 902 - 904
Main Authors Kotler, Eran, Segal, Eran
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2018
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Summary:Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection. Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2018.10.034