Low dose radiation overcomes diabetes-induced suppression of hippocampal neuronal cell proliferation in rats

We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1 Gy, 1 Gy and 10 Gy radiation was delivered, the dentate gyrus of hippocampus of streptozotocin (STZ)-induced diabetic rats were evaluated using...

Full description

Saved in:
Bibliographic Details
Published inJournal of Korean medical science Vol. 21; no. 3; pp. 500 - 505
Main Authors Kang, Jin Oh, Kim, Sang Ki, Hong, Seong Eon, Lee, Taeck Hyun, Kim, Chang Ju
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Academy of Medical Sciences 01.06.2006
Subjects
Animals
Apoptosis
Bromodeoxyuridine - pharmacology
Caspase 3 - metabolism
Cell Proliferation
Dentate Gyrus - drug effects
Dentate Gyrus - radiation effects
Diabetes Mellitus, Experimental - radiotherapy
Hippocampus - cytology
Hippocampus - metabolism
Hippocampus - radiation effects
In Situ Nick-End Labeling
Male
Neurons - metabolism
Original
Radiotherapy - methods
Rats
Rats, Sprague-Dawley
Online AccessGet full text

Cover

Abstract We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1 Gy, 1 Gy and 10 Gy radiation was delivered, the dentate gyrus of hippocampus of streptozotocin (STZ)-induced diabetic rats were evaluated using immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU), caspase-3, and terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) staining. The number of BrdU positive cells in the non-diabetic rats, diabetic rats without radiation, diabetic rats with 0.01 Gy radiation, diabetic rats with 0.1 Gy radiation, diabetic rats with 1 Gy radiation and diabetic rats with 10 Gy radiation were 55.4+/-8.5/mm2, 33.3+/-6.4/mm2, 67.7+/-10.5/mm2, 66.6+/-10.0/mm2, 23.5+/-6.3/mm2 and 14.3+/-7.2/mm2, respectively. The number of caspase-3 positive cells was 132.6+/-37.4/mm2, 378.6+/-99.1/mm2, 15.0+/-2.8/mm2, 57.1+/-16.9/mm2, 191.8+/-44.8/mm2 and 450.4+/-58.3/mm2, respectively. The number of TUNEL-positive cells was 24.5+/-2.0/mm2, 21.7+/-4.0/mm2, 20.4+/-2.0/mm2, 18.96+/-2.1/mm2, 58.3+/-7.9/mm2, and 106.0+/-9.8/mm2, respectively. These results suggest low doses of radiation paradoxically improved diabetes induced neuronal cell suppression in the hippocampal dentate gyrus of rat.
AbstractList We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1 Gy, 1 Gy and 10 Gy radiation was delivered, the dentate gyrus of hippocampus of streptozotocin (STZ)-induced diabetic rats were evaluated using immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU), caspase-3, and terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) staining. The number of BrdU positive cells in the non-diabetic rats, diabetic rats without radiation, diabetic rats with 0.01 Gy radiation, diabetic rats with 0.1 Gy radiation, diabetic rats with 1 Gy radiation and diabetic rats with 10 Gy radiation were 55.4+/-8.5/mm2, 33.3+/-6.4/mm2, 67.7+/-10.5/mm2, 66.6+/-10.0/mm2, 23.5+/-6.3/mm2 and 14.3+/-7.2/mm2, respectively. The number of caspase-3 positive cells was 132.6+/-37.4/mm2, 378.6+/-99.1/mm2, 15.0+/-2.8/mm2, 57.1+/-16.9/mm2, 191.8+/-44.8/mm2 and 450.4+/-58.3/mm2, respectively. The number of TUNEL-positive cells was 24.5+/-2.0/mm2, 21.7+/-4.0/mm2, 20.4+/-2.0/mm2, 18.96+/-2.1/mm2, 58.3+/-7.9/mm2, and 106.0+/-9.8/mm2, respectively. These results suggest low doses of radiation paradoxically improved diabetes induced neuronal cell suppression in the hippocampal dentate gyrus of rat.
We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1 Gy, 1 Gy and 10 Gy radiation was delivered, the dentate gyrus of hippocampus of streptozotocin (STZ)-induced diabetic rats were evaluated using immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU), caspase-3, and terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) staining. The number of BrdU positive cells in the non-diabetic rats, diabetic rats without radiation, diabetic rats with 0.01 Gy radiation, diabetic rats with 0.1 Gy radiation, diabetic rats with 1 Gy radiation and diabetic rats with 10 Gy radiation were 55.4±8.5/mm 2 , 33.3±6.4/mm 2 , 67.7±10.5/mm 2 , 66.6±10.0/mm 2 , 23.5±6.3/mm 2 and 14.3±7.2/mm 2 , respectively. The number of caspase-3 positive cells was 132.6±37.4/mm 2 , 378.6±99.1/mm 2 , 15.0±2.8/mm 2 , 57.1±16.9/mm 2 , 191.8±44.8/mm 2 and 450.4±58.3/mm 2 , respectively. The number of TUNEL-positive cells was 24.5±2.0/mm 2 , 21.7±4.0/mm 2 , 20.4±2.0/mm 2 , 18.96±2.1/mm 2 , 58.3±7.9/mm 2 , and 106.0±9.8/mm 2 , respectively. These results suggest low doses of radiation paradoxically improved diabetes induced neuronal cell suppression in the hippocampal dentate gyrus of rat.
Author Hong, Seong Eon
Kang, Jin Oh
Kim, Sang Ki
Lee, Taeck Hyun
Kim, Chang Ju
AuthorAffiliation Department of Physiology, School of Medicine, Kyung Hee University, Seoul, Korea
Department of Radiation Oncology, School of Medicine, Kyung Hee University, Seoul, Korea
AuthorAffiliation_xml – name: Department of Radiation Oncology, School of Medicine, Kyung Hee University, Seoul, Korea
– name: Department of Physiology, School of Medicine, Kyung Hee University, Seoul, Korea
Author_xml – sequence: 1
  givenname: Jin Oh
  surname: Kang
  fullname: Kang, Jin Oh
  email: kangjino@khmc.or.kr
  organization: Department of Radiation Oncology, School of Medicine, Kyung Hee University, Seoul, Korea. kangjino@khmc.or.kr
– sequence: 2
  givenname: Sang Ki
  surname: Kim
  fullname: Kim, Sang Ki
– sequence: 3
  givenname: Seong Eon
  surname: Hong
  fullname: Hong, Seong Eon
– sequence: 4
  givenname: Taeck Hyun
  surname: Lee
  fullname: Lee, Taeck Hyun
– sequence: 5
  givenname: Chang Ju
  surname: Kim
  fullname: Kim, Chang Ju
BackLink https://www.ncbi.nlm.nih.gov/pubmed/16778397$$D View this record in MEDLINE/PubMed
BookMark eNpVkc1u1DAUhS1URNuBF-iiyopdgv8db5BQxZ80EhtYW45zTd0mdmonRbw9HmbUwspH9rmfbX2X6CymCAhdEdwxxuW7u_u5dBRj2VHSsU5g_AJdEKH7VjKhzmrGhLS9ZvwcXZZyhzEVgrJX6JxIpXqm1QWa9ulXM6YCTbZjsGtIsUmPkF2aoTR1Z4AVShviuDkYm7ItS4ZS_tZ8cxuWJTk7L3ZqImw5xRocTFOz5DQFD_lIDLHi1_IavfR2KvDmtO7Qj08fv998afffPn-9-bBvHcd4bb0m2g1uFKO0ZGBWcm4lOK49plp5kAx7oYni2ArMQHFLRs-Z4IQPSta0Q--P3GUbZhgdxDXbySw5zDb_NskG8_9JDLfmZ3o0VFGtha6AtydATg8blNXMoRz-ZSOkrRjZ455yJWqRHosup1Iy-KdLCDYHSeYgyRwkGUoMM1VSHbr-93nPIycr7A-PLpQ-
CitedBy_id crossref_primary_10_1016_j_neures_2010_08_012
crossref_primary_10_3892_or_2023_8681
crossref_primary_10_1016_j_tox_2021_153030
crossref_primary_10_1007_s11356_019_06934_w
crossref_primary_10_1152_ajpendo_00265_2010
crossref_primary_10_1667_RR1950_1
crossref_primary_10_1007_s11033_022_08211_5
crossref_primary_10_1155_2012_291087
crossref_primary_10_1016_j_neubiorev_2013_03_010
crossref_primary_10_1186_1479_5876_12_75
crossref_primary_10_1667_RR1132_1
crossref_primary_10_1007_s00411_016_0665_2
crossref_primary_10_3346_jkms_2006_21_6_1103
crossref_primary_10_1210_en_2007_1340
crossref_primary_10_1016_j_ejphar_2012_10_020
crossref_primary_10_1152_jn_00866_2010
Cites_doi 10.1080/09553009414551081
10.1016/S0893-133X(99)00045-7
10.1080/13803390490514875
10.1016/S0304-3940(02)00591-8
10.1007/BF00417687
10.1038/386493a0
10.1097/00019052-200304000-00002
10.1001/archneur.61.5.661
10.1038/13197
10.1259/bjr/63353075
10.1523/JNEUROSCI.19-14-05792.1999
10.1038/4151030a
10.1080/09553008914551231
10.1016/S0006-3223(99)00247-4
10.1667/0033-7587(2000)154[0028:SLAMDI]2.0.CO;2
10.1055/s-2003-38202
10.1016/S0006-8993(02)02887-1
10.1016/S0306-4522(00)00151-2
10.1016/S0304-3940(00)01502-0
10.1016/j.brainres.2004.12.032
10.1016/S0027-5107(96)00121-2
10.1289/ehp.98106s1277
10.2337/diab.45.9.1259
10.1523/JNEUROSCI.16-06-02027.1996
ContentType Journal Article
Copyright Copyright © 2006 The Korean Academy of Medical Sciences 2006
Copyright_xml – notice: Copyright © 2006 The Korean Academy of Medical Sciences 2006
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.3346/jkms.2006.21.3.500
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1598-6357
EndPage 505
ExternalDocumentID 10_3346_jkms_2006_21_3_500
16778397
Genre Journal Article
GroupedDBID ---
29K
2WC
3O-
5-W
53G
5GY
8JR
8XY
9ZL
ADBBV
ADRAZ
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CGR
CS3
CUY
CVF
D-I
DIK
DU5
E3Z
EBS
ECM
EF.
EIF
EJD
F5P
FRP
GROUPED_DOAJ
GX1
HYE
KQ8
M48
M~E
NPM
O5R
O5S
OK1
PGMZT
RNS
RPM
TR2
W2D
XSB
AAYXX
CITATION
7X8
5PM
ID FETCH-LOGICAL-c400t-f919cbcd5d6a1b3a644a6ec49f0297fe630f591740a503e74a1df435414b76f43
IEDL.DBID RPM
ISSN 1011-8934
IngestDate Tue Sep 17 21:16:01 EDT 2024
Fri Aug 16 22:11:41 EDT 2024
Fri Aug 23 03:18:27 EDT 2024
Sat Sep 28 07:42:27 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c400t-f919cbcd5d6a1b3a644a6ec49f0297fe630f591740a503e74a1df435414b76f43
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729959/
PMID 16778397
PQID 68082475
PQPubID 23479
PageCount 6
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_2729959
proquest_miscellaneous_68082475
crossref_primary_10_3346_jkms_2006_21_3_500
pubmed_primary_16778397
PublicationCentury 2000
PublicationDate 2006-06-01
PublicationDateYYYYMMDD 2006-06-01
PublicationDate_xml – month: 06
  year: 2006
  text: 2006-06-01
  day: 01
PublicationDecade 2000
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Journal of Korean medical science
PublicationTitleAlternate J Korean Med Sci
PublicationYear 2006
Publisher The Korean Academy of Medical Sciences
Publisher_xml – name: The Korean Academy of Medical Sciences
References 8772732 - Diabetes. 1996 Sep;45(9):1259-66
10599477 - Biol Psychiatry. 1999 Dec 1;46(11):1472-9
9087407 - Nature. 1997 Apr 3;386(6624):493-5
12874001 - Cancer Res. 2003 Jul 15;63(14):4021-7
12137925 - Brain Res. 2002 Aug 16;946(2):221-31
15673519 - Br J Radiol. 2005 Jan;78(925):3-7
7488971 - Stem Cells. 1995 May;13 Suppl 1:7-20
12161261 - Neurosci Lett. 2002 Aug 23;329(1):53-6
10491610 - Nat Neurosci. 1999 Oct;2(10):894-7
11875571 - Nature. 2002 Feb 28;415(6875):1030-4
8604047 - J Neurosci. 1996 Mar 15;16(6):2027-33
9539019 - Environ Health Perspect. 1998 Feb;106 Suppl 1:277-83
7958534 - Diabetologia. 1994 Jul;37(7):643-50
11770125 - Folia Neuropathol. 2001;39(3):147-54
10856962 - Radiat Res. 2000 Jul;154(1):28-33
12644738 - Curr Opin Neurol. 2003 Apr;16(2):129-34
2569006 - Int J Radiat Biol. 1989 Jul;56(1):107-18
11027841 - Neurosci Lett. 2000 Oct 27;293(2):91-4
15748869 - Brain Res. 2005 Mar 15;1038(1):22-31
10407020 - J Neurosci. 1999 Jul 15;19(14):5792-801
15148141 - Arch Neurol. 2004 May;61(5):661-6
10432488 - Neuropsychopharmacology. 1999 Aug;21(2 Suppl):46S-51S
12669257 - Int J Sports Med. 2003 Feb;24(2):114-7
7916374 - Int J Radiat Biol. 1994 Aug;66(2):181-7
10924950 - Neuroscience. 2000;99(1):33-41
8946025 - Mutat Res. 1996 Nov 4;358(2):199-205
15590460 - J Clin Exp Neuropsychol. 2004 Nov;26(8):1044-80
Shukitt-Hale (10.3346/jkms.2006.21.3.500_ref18) 2000; 154
Awad (10.3346/jkms.2006.21.3.500_ref3) 2004; 26
Li (10.3346/jkms.2006.21.3.500_ref27) 2002; 946
Arvanitakis (10.3346/jkms.2006.21.3.500_ref4) 2004; 61
Feinendegen (10.3346/jkms.2006.21.3.500_ref21) 1995; 13
Shadley (10.3346/jkms.2006.21.3.500_ref24) 1989; 56
Biessels (10.3346/jkms.2006.21.3.500_ref1) 1994; 37
Revsin (10.3346/jkms.2006.21.3.500_ref23) 2005; 1038
Kempermann (10.3346/jkms.2006.21.3.500_ref8) 1997; 386
Mizumatsu (10.3346/jkms.2006.21.3.500_ref15) 2003; 63
Lee (10.3346/jkms.2006.21.3.500_ref22) 2002; 329
Feinendegen (10.3346/jkms.2006.21.3.500_ref25) 1996; 358
Feinendegen (10.3346/jkms.2006.21.3.500_ref19) 2005; 78
Tada (10.3346/jkms.2006.21.3.500_ref16) 2000; 99
Jackson-Guilford (10.3346/jkms.2006.21.3.500_ref5) 2000; 293
van Praag (10.3346/jkms.2006.21.3.500_ref6) 2002; 415
Wolff (10.3346/jkms.2006.21.3.500_ref20) 1998; 106
Ferrer (10.3346/jkms.2006.21.3.500_ref14) 1994; 66
Biessels (10.3346/jkms.2006.21.3.500_ref2) 1996; 45
Tanapat (10.3346/jkms.2006.21.3.500_ref9) 1999; 19
Monje (10.3346/jkms.2006.21.3.500_ref17) 2003; 16
Kim (10.3346/jkms.2006.21.3.500_ref10) 2003; 24
Gould (10.3346/jkms.2006.21.3.500_ref12) 1999; 46
Gould (10.3346/jkms.2006.21.3.500_ref7) 1999; 21
Cameron (10.3346/jkms.2006.21.3.500_ref11) 1999; 2
Piotrowski (10.3346/jkms.2006.21.3.500_ref26) 2001; 39
Kuhn (10.3346/jkms.2006.21.3.500_ref13) 1996; 16
References_xml – volume: 66
  start-page: 181
  year: 1994
  ident: 10.3346/jkms.2006.21.3.500_ref14
  publication-title: Int J Radiat Biol
  doi: 10.1080/09553009414551081
  contributor:
    fullname: Ferrer
– volume: 21
  start-page: 46S
  year: 1999
  ident: 10.3346/jkms.2006.21.3.500_ref7
  publication-title: Neuropsychopharmacology
  doi: 10.1016/S0893-133X(99)00045-7
  contributor:
    fullname: Gould
– volume: 26
  start-page: 1044
  year: 2004
  ident: 10.3346/jkms.2006.21.3.500_ref3
  publication-title: J Clin Exp Neuropsychol
  doi: 10.1080/13803390490514875
  contributor:
    fullname: Awad
– volume: 329
  start-page: 53
  year: 2002
  ident: 10.3346/jkms.2006.21.3.500_ref22
  publication-title: Neurosci Lett
  doi: 10.1016/S0304-3940(02)00591-8
  contributor:
    fullname: Lee
– volume: 37
  start-page: 643
  year: 1994
  ident: 10.3346/jkms.2006.21.3.500_ref1
  publication-title: Diabetologia
  doi: 10.1007/BF00417687
  contributor:
    fullname: Biessels
– volume: 386
  start-page: 493
  year: 1997
  ident: 10.3346/jkms.2006.21.3.500_ref8
  publication-title: Nature
  doi: 10.1038/386493a0
  contributor:
    fullname: Kempermann
– volume: 16
  start-page: 129
  year: 2003
  ident: 10.3346/jkms.2006.21.3.500_ref17
  publication-title: Curr Opin Neurol
  doi: 10.1097/00019052-200304000-00002
  contributor:
    fullname: Monje
– volume: 61
  start-page: 661
  year: 2004
  ident: 10.3346/jkms.2006.21.3.500_ref4
  publication-title: Arch Neurol
  doi: 10.1001/archneur.61.5.661
  contributor:
    fullname: Arvanitakis
– volume: 2
  start-page: 894
  year: 1999
  ident: 10.3346/jkms.2006.21.3.500_ref11
  publication-title: Nat Neurosci
  doi: 10.1038/13197
  contributor:
    fullname: Cameron
– volume: 78
  start-page: 3
  year: 2005
  ident: 10.3346/jkms.2006.21.3.500_ref19
  publication-title: Br J Radiol
  doi: 10.1259/bjr/63353075
  contributor:
    fullname: Feinendegen
– volume: 39
  start-page: 147
  year: 2001
  ident: 10.3346/jkms.2006.21.3.500_ref26
  publication-title: Folia Neuropathol
  contributor:
    fullname: Piotrowski
– volume: 19
  start-page: 5792
  year: 1999
  ident: 10.3346/jkms.2006.21.3.500_ref9
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.19-14-05792.1999
  contributor:
    fullname: Tanapat
– volume: 415
  start-page: 1030
  year: 2002
  ident: 10.3346/jkms.2006.21.3.500_ref6
  publication-title: Nature
  doi: 10.1038/4151030a
  contributor:
    fullname: van Praag
– volume: 56
  start-page: 107
  year: 1989
  ident: 10.3346/jkms.2006.21.3.500_ref24
  publication-title: Int J Radiat Biol
  doi: 10.1080/09553008914551231
  contributor:
    fullname: Shadley
– volume: 46
  start-page: 1472
  year: 1999
  ident: 10.3346/jkms.2006.21.3.500_ref12
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(99)00247-4
  contributor:
    fullname: Gould
– volume: 154
  start-page: 28
  year: 2000
  ident: 10.3346/jkms.2006.21.3.500_ref18
  publication-title: Radiat Res
  doi: 10.1667/0033-7587(2000)154[0028:SLAMDI]2.0.CO;2
  contributor:
    fullname: Shukitt-Hale
– volume: 24
  start-page: 114
  year: 2003
  ident: 10.3346/jkms.2006.21.3.500_ref10
  publication-title: Int J Sports Med
  doi: 10.1055/s-2003-38202
  contributor:
    fullname: Kim
– volume: 946
  start-page: 221
  year: 2002
  ident: 10.3346/jkms.2006.21.3.500_ref27
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(02)02887-1
  contributor:
    fullname: Li
– volume: 13
  start-page: 7
  issue: Suppl 1
  year: 1995
  ident: 10.3346/jkms.2006.21.3.500_ref21
  publication-title: Stem Cells
  contributor:
    fullname: Feinendegen
– volume: 99
  start-page: 33
  year: 2000
  ident: 10.3346/jkms.2006.21.3.500_ref16
  publication-title: Neuroscience
  doi: 10.1016/S0306-4522(00)00151-2
  contributor:
    fullname: Tada
– volume: 293
  start-page: 91
  year: 2000
  ident: 10.3346/jkms.2006.21.3.500_ref5
  publication-title: Neurosci Lett
  doi: 10.1016/S0304-3940(00)01502-0
  contributor:
    fullname: Jackson-Guilford
– volume: 1038
  start-page: 22
  year: 2005
  ident: 10.3346/jkms.2006.21.3.500_ref23
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2004.12.032
  contributor:
    fullname: Revsin
– volume: 358
  start-page: 199
  year: 1996
  ident: 10.3346/jkms.2006.21.3.500_ref25
  publication-title: Mutat Res
  doi: 10.1016/S0027-5107(96)00121-2
  contributor:
    fullname: Feinendegen
– volume: 106
  start-page: 277
  issue: Suppl 1
  year: 1998
  ident: 10.3346/jkms.2006.21.3.500_ref20
  publication-title: Environ Health Perspect
  doi: 10.1289/ehp.98106s1277
  contributor:
    fullname: Wolff
– volume: 45
  start-page: 1259
  year: 1996
  ident: 10.3346/jkms.2006.21.3.500_ref2
  publication-title: Diabetes
  doi: 10.2337/diab.45.9.1259
  contributor:
    fullname: Biessels
– volume: 63
  start-page: 4021
  year: 2003
  ident: 10.3346/jkms.2006.21.3.500_ref15
  publication-title: Cancer Res
  contributor:
    fullname: Mizumatsu
– volume: 16
  start-page: 2027
  year: 1996
  ident: 10.3346/jkms.2006.21.3.500_ref13
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.16-06-02027.1996
  contributor:
    fullname: Kuhn
SSID ssj0025523
Score 1.8701298
Snippet We investigated the effect of low dose radiation on diabetes induced suppression of neurogenesis in the hippocampal dentate gyrus of rat. After 0.01 Gy, 0.1...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 500
SubjectTerms Animals
Apoptosis
Bromodeoxyuridine - pharmacology
Caspase 3 - metabolism
Cell Proliferation
Dentate Gyrus - drug effects
Dentate Gyrus - radiation effects
Diabetes Mellitus, Experimental - radiotherapy
Hippocampus - cytology
Hippocampus - metabolism
Hippocampus - radiation effects
In Situ Nick-End Labeling
Male
Neurons - metabolism
Original
Radiotherapy - methods
Rats
Rats, Sprague-Dawley
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1LS8NAEF6KgngR39bnHrxJSnazSZqDiIiliPVkobew2ezSYk1ik6L-e2fyqNYH3kKyzJJ5ZL6ZncwQco61X10wG4tJpi3hOhJMKggsHtvGBL4xqsx3DB68_lDcjdxRizTjjmoG5r-GdjhPajibdt5e3q_A4C8x4nTwhPLpuWq83eGs43RcG0L4VS7gEZbyicWpAqBnXhXcM2aBnxbVTzR_0Fh2VD_Q5_ciyi9eqbdJNmo4Sa8r-W-Rlk62ydqgPjDfIdP79JXGaa7pDJsQoBQoFm2CnumcNolXCwJzEHFM83lWF8bCMkPHkywDXwdfjCktG1_iXpjqpxkO-zG6Uh86SYB8ke-SYe_28aZv1QMWLAWmW1gGxKIiFbuxJ1nkSMBG0tNKBAZHWhntObZxIZ4TtnRtR_tCstgAvhJMRL4HV3tkJUkTfUAojxRnUkgRaCGU8qW0bWV38U6sAaK0yUXDzTCr-miEEH8g70PkPY7D9ELOQicE3rfJWcPwENQdX0wmOp3nIU4K4QLp7Vfs_6SGrfAAXbWJvySYxQJspL38JJmMy4baHCKMwA0O_931iKxXKRjMwhyTlWI21ycASorotNS0Dwon46c
  priority: 102
  providerName: Scholars Portal
Title Low dose radiation overcomes diabetes-induced suppression of hippocampal neuronal cell proliferation in rats
URI https://www.ncbi.nlm.nih.gov/pubmed/16778397
https://search.proquest.com/docview/68082475
https://pubmed.ncbi.nlm.nih.gov/PMC2729959
Volume 21
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj5swELayOVS9VH1tm26b-tDbCoKxDeFYpY3SB92o2ki5IWNsbVQCqCTav98ZDG3S3npBiIdBM2P8jf3xDSHvkPs1h27jMcWMJyRX0KWSxAuLwNoktlZ38x3pt2i1EZ-3cjsicvgXpiPt63znV-Xer3Z3Hbey2evZwBObrdNFCIgwkcnsglzEnA8pep9lSRk6Vj1jHgzGwv0pwzkuZf7YO4VuP2Q-92XQ1YFDCTWOok-nA9M_aPNv0uTJKLR8TB718JG-d6_5hIxM9ZQ8SPsF8mek_Frf0w91a-h3FB1Aq9MbiFaIK9PSnv7SepCIg0sLijU9HRG2orWlq13TwNgGX4iSdqod-KyFKUu6xuI-1rhwobsKmj-0z8lm-fF2sfL6ggqehq568Cy4Qee6kEWkWM4VYCEVGS0SiyWsrIl4YCXkbyJQMuAmFooVFvCUYCKPI9i7JOOqrsxLQsNch0wJJRIjhNaxUkGggzkeKQxAkgm5HqyZNU43I4N8A92QoRuw_GWUhSzjGbhhQt4OBs8gvHHNQlWmPrYZVgYJBbb3wpn_T2u93yYkPnPM7wtQOPv8DMRTJ6Ddx8-r_77zijx0UzE4G_OajA8_j-YNgJNDPgVY_ukLbFMxn3aB-Qv-Mufm
link.rule.ids 230,315,733,786,790,891,2236,24346,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkYBLeRaWV33ghpKNX0lzRAvVArulQi3qzXIcW6yaTVZNVkj8embiBNpygluUhyPrm7Fn7M_fEPIGuV-H4DYRM8xFUgkDLpXnES8T7_PMe9uvdyyP0_mZ_HSuzneIGs_C9KR9W6ziulrH9ep7z63crO105IlNT5YzDhFhrvLpLXIb_JWrMUkf8iyleODVMxbBdCzDWRkhcDPzYh00umPOYhGrpK8EhyJqAmWfrk5Nf8WbN2mTV-aho_vk29iDQD-5iLddEdufN8Qd_7mLD8jeEJnSd-HxQ7Lj6kfkznLYe39MqkXzg75vWke_op4BAkq_gCOAybqWDsyaNoIcH6ylpFguNHBsa9p4Ol9tNjBtwuBT0V4QBP81c1VFT7BukHfBEumqhua79gk5O_pwOptHQ62GyMIo0EUeELaFLVWZGlYIA2GWSZ2VucfqWN6lIvEKUkOZGJUIl0nDSg-hmmSyyFK42ie7dVO7Z4TywnJmpJG5k9LazJgksckh3ikdRDsT8naESW-CJIeGVAbx1YgvVtZMNWdaaMB3Qg5GJDV4Dm6HmNo121Zj0REusb2nAdc_rQ0GMSHZNcR_v4Ca3NefAI69NveA2_P__vKA3J2fLhd68fH48wtyL6z44KLPS7LbXW7dK4iBuuJ1b_G_ADsxCCM
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELWgSBUXKN8LLfWBG0o2_kqaI9p2tUC3rBCVKi6R49hi1WwSkayQ-PXMxAlsy623KHEcWW_GnrFf3hDyDrlfJ-A2AdPMBlIJDS6VpgEvIufSxDnT73csL-LFpfx0pa52Sn31pH2Tr8Oq3ITV-kfPrWw2ZjryxKar5YxDRJiqdNoUbnqfPACf5cmYqA-5llLcc-sZC2BJlv5_GSHwQPN643W6Q85CEaqorwaHQmoCpZ92l6f_Ys7b1MmdtWj-mHwfR-EpKNfhtstD8_uWwOOdhnlAHg0RKv3gmzwh92z1lOwvhzP4Z6Q8r3_R07q19CvqGiCw9As4BJiubenAsGkDyPXBagqKZUM917aitaOLddPA8gmTUEl7YRD81syWJV1h_SBnvUXSdQXdd-1zcjk_-zZbBEPNhsDAbNAFDpA2uSlUEWuWCw3hlo6tkanDKlnOxiJyClJEGWkVCZtIzQoHIZtkMk9iuHpB9qq6sq8I5bnhTEstUyulMYnWUWSiE7xTWIh6JuT9CFXWeGmODFIaxDhDjLHCZpxxlokMMJ6Q4xHNDDwIj0V0Zettm2HxES6xv5ce23-9DUYxIckN1P82QG3um08Ay16je8Du9Z3fPCb7q9N5dv7x4vMb8tBv_ODezyHZ635u7RGEQl3-tjf6P3oJCqM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Low+dose+radiation+overcomes+diabetes-induced+suppression+of+hippocampal+neuronal+cell+proliferation+in+rats&rft.jtitle=Journal+of+Korean+medical+science&rft.au=Kang%2C+Jin+Oh&rft.au=Kim%2C+Sang+Ki&rft.au=Hong%2C+Seong+Eon&rft.au=Lee%2C+Taeck+Hyun&rft.date=2006-06-01&rft.issn=1011-8934&rft.volume=21&rft.issue=3&rft.spage=500&rft.epage=505&rft_id=info:doi/10.3346%2Fjkms.2006.21.3.500&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1011-8934&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1011-8934&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1011-8934&client=summon