Shielded geomagnetic field accelerates glucose consumption in human neuroblastoma cells by promoting anaerobic glycolysis

A shielded geomagnetic field, also called the hypomagnetic field (HMF), interferes with the metabolic processes of various cells and animals exhibiting diverse effects in different models, however, its underlying mechanism remains largely unknown. In this study, we assessed the effect on the energy...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 601; pp. 101 - 108
Main Authors Wang, Guo-mi, Fu, Jing-peng, Mo, Wei-chuan, Zhang, Hai-tao, Liu, Ying, He, Rong-qiao
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.04.2022
Subjects
Anaerobiosis
Animals
Cell Line, Tumor
Cell metabolism
Cell proliferation
Glucose
Glycolysis
Humans
Hypomagnetic field
Magnetic Fields
Neuroblastoma - metabolism
Cell proliferation
HMF
GMF
LDH
Cell metabolism
Glycolysis
Hypomagnetic field
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Summary:A shielded geomagnetic field, also called the hypomagnetic field (HMF), interferes with the metabolic processes of various cells and animals exhibiting diverse effects in different models, however, its underlying mechanism remains largely unknown. In this study, we assessed the effect on the energy metabolism of SH-SY5Y cells in HMF and found that HMF-induced cell proliferation depends on glucose supply. HMF promoted SH-SY5Y cell proliferation by increasing glucose consumption rate via up-regulating anaerobic glycolysis in the cells. Increased activity of LDH, a key member of glycolysis, was possibly a direct response to HMF-induced cell proliferation. Thus, we unveiled a novel subcellular mechanism underlying the HMF-induced cellular response: the up-regulation of anaerobic glycolysis and repression of oxidative stress shifted cellular metabolism more towards the Warburg effect commonly observed in cancer metabolism. We suggest that cellular metabolic profiles of various cell types may determine HMF-induced cellular effects, and a magnetic field can be applied as a non-invasive regulator of cell metabolism. •Hypomagnetic field exposure accelerates glucose consumption by promoting glycolysis.•Hypomagnetic field regulates cell metabolism via up-regulating LDH activity.•HMF shifts cellular metabolism towards to the enhanced Warburg Effect.
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ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2022.01.114